Difference between revisions of "GNA13"

Jump to: navigation, search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
imported>Rjwilmsi
m (Journal cites:, added 1 PMC)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+
{{Infobox_gene}}
{{PBB_Controls
+
'''Guanine nucleotide-binding protein subunit alpha-13''' is a [[protein]] that in humans is encoded by the ''GNA13'' [[gene]].<ref name="pmid7791744">{{cite journal | vauthors = Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD | title = Expression of GTP-binding protein alpha subunits in human thymocytes | journal = Molecular and Cellular Biochemistry | volume = 144 | issue = 1 | pages = 45–51 | date = Mar 1995 | pmid = 7791744 | pmc = | doi = 10.1007/BF00926739 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10672| accessdate = }}</ref>
| update_page = yes
 
| require_manual_inspection = no
 
| update_protein_box = yes
 
| update_summary = yes
 
| update_citations = yes
 
}}
 
  
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+
== Interactions ==
{{GNF_Protein_box
 
| image = PBB_Protein_GNA13_image.jpg
 
| Name = Guanine nucleotide binding protein (G protein), alpha 13
 
| HGNCid = 4381
 
| Symbol = GNA13
 
| AltSymbols =; G13; MGC46138
 
| OMIM = 604406
 
| ECnumber = 
 
| Homologene = 55976
 
| MGIid = 95768
 
| GeneAtlas_image1 = PBB_GE_GNA13_206917_at_tn.png
 
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
 
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
 
| Process = {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}}
 
| Orthologs = {{GNF_Ortholog_box
 
    | Hs_EntrezGene = 10672
 
    | Hs_Ensembl = ENSG00000120063
 
    | Hs_RefseqProtein = NP_006563
 
    | Hs_RefseqmRNA = NM_006572
 
    | Hs_GenLoc_db = 
 
    | Hs_GenLoc_chr = 17
 
    | Hs_GenLoc_start = 60437296
 
    | Hs_GenLoc_end = 60483216
 
    | Hs_Uniprot = Q14344
 
    | Mm_EntrezGene = 14674
 
    | Mm_Ensembl = ENSMUSG00000020611
 
    | Mm_RefseqmRNA = NM_010303
 
    | Mm_RefseqProtein = NP_034433
 
    | Mm_GenLoc_db = 
 
    | Mm_GenLoc_chr = 11
 
    | Mm_GenLoc_start = 109178921
 
    | Mm_GenLoc_end = 109212576
 
    | Mm_Uniprot = Q3UE40
 
  }}
 
}}
 
{{SI}}
 
  
 +
GNA13 has been shown to [[Protein-protein interaction|interact]] with:
 +
{{div col|colwidth=20em}}
 +
* [[AKAP3]],<ref name = pmid11696326>{{cite journal | vauthors = Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA | title = Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation | journal = Current Biology | volume = 11 | issue = 21 | pages = 1686–90 | date = Oct 2001 | pmid = 11696326 | doi =  10.1016/s0960-9822(01)00530-9}}</ref>
 +
* [[ARHGEF12]],<ref name = pmid11094164>{{cite journal | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho | journal = FEBS Letters | volume = 485 | issue = 2–3 | pages = 183–8 | date = Nov 2000 | pmid = 11094164 | doi =  10.1016/s0014-5793(00)02224-9}}</ref><ref name = pmid12515866>{{cite journal | vauthors = Suzuki N, Nakamura S, Mano H, Kozasa T | title = Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 2 | pages = 733–8 | date = Jan 2003 | pmid = 12515866 | pmc = 141065 | doi = 10.1073/pnas.0234057100 }}</ref>
 +
* [[ARHGEF1]],<ref name = pmid14634662>{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nature Cell Biology | volume = 5 | issue = 12 | pages = 1095–103 | date = Dec 2003 | pmid = 14634662 | doi = 10.1038/ncb1065 }}</ref><ref name = pmid12681510>{{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment | journal = FEBS Letters | volume = 540 | issue = 1–3 | pages = 211–6 | date = Apr 2003 | pmid = 12681510 | doi =  10.1016/s0014-5793(03)00267-9}}</ref><ref name = pmid9641916>{{cite journal | vauthors = Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G | title = Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 | journal = Science | volume = 280 | issue = 5372 | pages = 2112–4 | date = Jun 1998 | pmid = 9641916 | doi =  10.1126/science.280.5372.2112}}</ref>
 +
* [[RIC8A]],<ref name = pmid12509430>{{cite journal | vauthors = Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8356–62 | date = Mar 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 }}</ref>  <ref name=pmid21771786>{{cite journal | vauthors = Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY | title = Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization | journal = The Journal of Biological Chemistry | volume = 286 | issue = 35 | pages = 31055–61 | date = September 2011 | pmid = 21771786 | doi = 10.1074/jbc.M111.253427 | pmc=3162464}}</ref>      and
 +
* [[Radixin]].<ref name = pmid10816569>{{cite journal | vauthors = Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA | title = Conformational activation of radixin by G13 protein alpha subunit | journal = The Journal of Biological Chemistry | volume = 275 | issue = 34 | pages = 26206–12 | date = Aug 2000 | pmid = 10816569 | doi = 10.1074/jbc.M001863200 }}</ref>
 +
{{Div col end}}
  
'''Guanine nucleotide binding protein (G protein), alpha 13''', also known as '''GNA13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10672| accessdate = }}</ref>
+
== Clinical significance ==
  
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
+
Recurrent mutations in this gene have been associated to cases of [[diffuse large B-cell lymphoma]].<ref name="MorinMendez-Lago2011">{{cite journal | vauthors = Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA | title = Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma | journal = Nature | volume = 476 | issue = 7360 | pages = 298–303  | date = Aug 2011 | pmid = 21796119 | pmc = 3210554 | doi = 10.1038/nature10351 }}</ref><ref name=pmid.22343534>{{cite journal | vauthors = Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR | title = Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 10 | pages = 3879–84 | date = Mar 2012 | pmid = 22343534 | pmc = 3309757 | doi = 10.1073/pnas.1121343109 }}</ref>
{{PBB_Summary
 
| section_title =  
 
| summary_text =  
 
}}
 
  
==See also==
+
== See also ==
 
* [[G protein]]
 
* [[G protein]]
  
==References==
+
== References ==
{{reflist|2}}
+
{{reflist|33wm}}
  
==Further reading==
+
== Further reading ==
{{refbegin | 2}}
+
{{refbegin |33em}}
*{{cite journal | author=Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Liya Yin, Xu SM, and Coughlin SR |title=Essential role for Galpha 13 in endothelial cells during embryonic development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 22 |pages= 8281–8286 |year= 2005 |pmid= 15919816 |doi= 10.1073/pnas.0503326102 }}
+
* {{cite journal | vauthors = Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR | title = Essential role for Galpha13 in endothelial cells during embryonic development | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 23 | pages = 8281–8286 | date = Jun 2005 | pmid = 15919816 | pmc = 1149452 | doi = 10.1073/pnas.0503326102 }}
{{PBB_Further_reading
+
* {{cite journal | vauthors = Downes GB, Gautam N | title = The G protein subunit gene families | journal = Genomics | volume = 62 | issue = 3 | pages = 544–52 | year = 2000 | date = Dec 1999 | pmid = 10644457 | doi = 10.1006/geno.1999.5992 }}
| citations =
+
* {{cite journal | vauthors = Offermanns S, Laugwitz KL, Spicher K, Schultz G | title = G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 2 | pages = 504–8  | date = Jan 1994 | pmid = 8290554 | pmc = 42977 | doi = 10.1073/pnas.91.2.504 }}
*{{cite journal | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544–52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
+
* {{cite journal | vauthors = Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G | title = The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 1 | pages = 116–20  | date = Jan 1996 | pmid = 8552586 | pmc = 40189 | doi = 10.1073/pnas.93.1.116 }}
*{{cite journal | author=Kabouridis PS, Waters ST, Escobar S, ''et al.'' |title=Expression of GTP-binding protein alpha subunits in human thymocytes. |journal=Mol. Cell. Biochem. |volume=144 |issue= 1 |pages= 45–51 |year= 1995 |pmid= 7791744 |doi= }}
+
* {{cite journal | vauthors = Offermanns S, Hu YH, Simon MI | title = Galpha12 and galpha13 are phosphorylated during platelet activation | journal = The Journal of Biological Chemistry | volume = 271 | issue = 42 | pages = 26044–8  | date = Oct 1996 | pmid = 8824244 | doi = 10.1074/jbc.271.42.26044 }}
*{{cite journal | author=Offermanns S, Laugwitz KL, Spicher K, Schultz G |title=G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 2 |pages= 504–8 |year= 1994 |pmid= 8290554 |doi= }}
+
* {{cite journal | vauthors = Offermanns S, Mancino V, Revel JP, Simon MI | title = Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency | journal = Science | volume = 275 | issue = 5299 | pages = 533–6  | date = Jan 1997 | pmid = 8999798 | doi = 10.1126/science.275.5299.533 }}
*{{cite journal  | author=Laugwitz KL, Allgeier A, Offermanns S, ''et al.'' |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116–20 |year= 1996 |pmid= 8552586 |doi= }}
+
* {{cite journal | vauthors = Macrez-Leprêtre N, Kalkbrenner F, Morel JL, Schultz G, Mironneau J | title = G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes | journal = The Journal of Biological Chemistry | volume = 272 | issue = 15 | pages = 10095–102  | date = Apr 1997 | pmid = 9092554 | doi = 10.1074/jbc.272.15.10095 }}
*{{cite journal | author=Offermanns S, Hu YH, Simon MI |title=Galpha12 and galpha13 are phosphorylated during platelet activation. |journal=J. Biol. Chem. |volume=271 |issue= 42 |pages= 26044–8 |year= 1996 |pmid= 8824244 |doi= }}
+
* {{cite journal | vauthors = Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G | title = Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 | journal = Science | volume = 280 | issue = 5372 | pages = 2112–4  | date = Jun 1998 | pmid = 9641916 | doi = 10.1126/science.280.5372.2112 }}
*{{cite journal | author=Offermanns S, Mancino V, Revel JP, Simon MI |title=Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. |journal=Science |volume=275 |issue= 5299 |pages= 533–6 |year= 1997 |pmid= 8999798 |doi= }}
+
* {{cite journal | vauthors = Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS | title = A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho | journal = The Journal of Biological Chemistry | volume = 274 | issue = 9 | pages = 5868–79  | date = Feb 1999 | pmid = 10026210 | doi = 10.1074/jbc.274.9.5868 }}
*{{cite journal | author=Macrez-Leprêtre N, Kalkbrenner F, Morel JL, ''et al.'' |title=G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10095–102 |year= 1997 |pmid= 9092554 |doi= }}
+
* {{cite journal | vauthors = Becker KP, Garnovskaya M, Gettys T, Halushka PV | title = Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling | journal = Biochimica et Biophysica Acta | volume = 1450 | issue = 3 | pages = 288–96  | date = Jul 1999 | pmid = 10395940 | doi = 10.1016/S0167-4889(99)00068-3 }}
*{{cite journal | author=Hart MJ, Jiang X, Kozasa T, ''et al.'' |title=Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. |journal=Science |volume=280 |issue= 5372 |pages= 2112–4 |year= 1998 |pmid= 9641916 |doi= }}
+
* {{cite journal | vauthors = Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR | title = Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins | journal = The Journal of Biological Chemistry | volume = 274 | issue = 39 | pages = 27351–8  | date = Sep 1999 | pmid = 10488065 | doi = 10.1074/jbc.274.39.27351 }}
*{{cite journal | author=Fukuhara S, Murga C, Zohar M, ''et al.'' |title=A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5868–79 |year= 1999 |pmid= 10026210 |doi= }}
+
* {{cite journal | vauthors = Brydon L, Roka F, Petit L, de Coppet P, Tissot M, Barrett P, Morgan PJ, Nanoff C, Strosberg AD, Jockers R | title = Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins | journal = Molecular Endocrinology (Baltimore, Md.) | volume = 13 | issue = 12 | pages = 2025–38 | year = 2000 | date = Dec 1999 | pmid = 10598579 | doi = 10.1210/me.13.12.2025 }}
*{{cite journal | author=Becker KP, Garnovskaya M, Gettys T, Halushka PV |title=Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling. |journal=Biochim. Biophys. Acta |volume=1450 |issue= 3 |pages= 288–96 |year= 1999 |pmid= 10395940 |doi= }}
+
* {{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding | journal = The Journal of Biological Chemistry | volume = 275 | issue = 20 | pages = 14992–9  | date = May 2000 | pmid = 10747909 | doi = 10.1074/jbc.M000415200 }}
*{{cite journal | author=Windh RT, Lee MJ, Hla T, ''et al.'' |title=Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27351–8 |year= 1999 |pmid= 10488065 |doi= }}
+
* {{cite journal | vauthors = Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA | title = Conformational activation of radixin by G13 protein alpha subunit | journal = The Journal of Biological Chemistry | volume = 275 | issue = 34 | pages = 26206–12  | date = Aug 2000 | pmid = 10816569 | doi = 10.1074/jbc.M001863200 }}
*{{cite journal | author=Brydon L, Roka F, Petit L, ''et al.'' |title=Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2025–38 |year= 2000 |pmid= 10598579 |doi= }}
+
* {{cite journal | vauthors = Shi CS, Sinnarajah S, Cho H, Kozasa T, Kehrl JH | title = G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription | journal = The Journal of Biological Chemistry | volume = 275 | issue = 32 | pages = 24470–6  | date = Aug 2000 | pmid = 10821841 | doi = 10.1074/jbc.M908449199 }}
*{{cite journal | author=Bhattacharyya R, Wedegaertner PB |title=Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14992–9 |year= 2000 |pmid= 10747909 |doi= 10.1074/jbc.M000415200 }}
+
* {{cite journal | vauthors = Ponimaskin E, Behn H, Adarichev V, Voyno-Yasenetskaya TA, Offermanns S, Schmidt MF | title = Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation | journal = FEBS Letters | volume = 478 | issue = 1–2 | pages = 173–7  | date = Jul 2000 | pmid = 10922491 | doi = 10.1016/S0014-5793(00)01845-7 }}
*{{cite journal | author=Vaiskunaite R, Adarichev V, Furthmayr H, ''et al.'' |title=Conformational activation of radixin by G13 protein alpha subunit. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26206–12 |year= 2000 |pmid= 10816569 |doi= 10.1074/jbc.M001863200 }}
+
* {{cite journal | vauthors = Jin S, Exton JH | title = Activation of RhoA by association of Galpha(13) with Dbl | journal = Biochemical and Biophysical Research Communications | volume = 277 | issue = 3 | pages = 718–21  | date = Nov 2000 | pmid = 11062019 | doi = 10.1006/bbrc.2000.3744 }}
*{{cite journal | author=Shi CS, Sinnarajah S, Cho H, ''et al.'' |title=G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24470–6 |year= 2000 |pmid= 10821841 |doi= 10.1074/jbc.M908449199 }}
+
* {{cite journal | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho | journal = FEBS Letters | volume = 485 | issue = 2–3 | pages = 183–8  | date = Nov 2000 | pmid = 11094164 | doi = 10.1016/S0014-5793(00)02224-9 }}
*{{cite journal | author=Ponimaskin E, Behn H, Adarichev V, ''et al.'' |title=Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation. |journal=FEBS Lett. |volume=478 |issue= 1-2 |pages= 173–7 |year= 2000 |pmid= 10922491 |doi= }}
+
* {{cite journal | vauthors = Meigs TE, Fields TA, McKee DD, Casey PJ | title = Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 2 | pages = 519–24  | date = Jan 2001 | pmid = 11136230 | pmc = 14619 | doi = 10.1073/pnas.021350998 }}
*{{cite journal | author=Jin S, Exton JH |title=Activation of RhoA by association of Galpha(13) with Dbl. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 718–21 |year= 2000 |pmid= 11062019 |doi= 10.1006/bbrc.2000.3744 }}
 
*{{cite journal | author=Fukuhara S, Chikumi H, Gutkind JS |title=Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. |journal=FEBS Lett. |volume=485 |issue= 2-3 |pages= 183–8 |year= 2000 |pmid= 11094164 |doi=  }}
 
*{{cite journal  | author=Meigs TE, Fields TA, McKee DD, Casey PJ |title=Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 519–24 |year= 2001 |pmid= 11136230 |doi= 10.1073/pnas.021350998 }}
 
}}
 
 
{{refend}}
 
{{refend}}
  
{{gene-17-stub}}
+
{{PDB Gallery|geneid=10672}}
 +
{{Intracellular signaling peptides and proteins}}
 +
{{GTPases}}
 +
 
 
{{NLM content}}
 
{{NLM content}}
{{GTPases}}
 
{{WikiDoc Help Menu}}
 
{{WS}}
 

Latest revision as of 13:01, 5 March 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene.[1][2]

Interactions

GNA13 has been shown to interact with:

Clinical significance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[12][13]

See also

References

  1. Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (Mar 1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Molecular and Cellular Biochemistry. 144 (1): 45–51. doi:10.1007/BF00926739. PMID 7791744.
  2. "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13".
  3. Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA (Oct 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Current Biology. 11 (21): 1686–90. doi:10.1016/s0960-9822(01)00530-9. PMID 11696326.
  4. Fukuhara S, Chikumi H, Gutkind JS (Nov 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/s0014-5793(00)02224-9. PMID 11094164.
  5. Suzuki N, Nakamura S, Mano H, Kozasa T (Jan 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  6. Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (Dec 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
  7. Bhattacharyya R, Wedegaertner PB (Apr 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Letters. 540 (1–3): 211–6. doi:10.1016/s0014-5793(03)00267-9. PMID 12681510.
  8. Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
  9. Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
  10. Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.
  11. Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (Aug 2000). "Conformational activation of radixin by G13 protein alpha subunit". The Journal of Biological Chemistry. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
  12. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA (Aug 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature. 476 (7360): 298–303. doi:10.1038/nature10351. PMC 3210554. PMID 21796119.
  13. Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Linked-in.jpg