Formyl-CoA transferase

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In enzymology, a formyl-CoA transferase (EC is an enzyme that catalyzes the chemical reaction

formyl-CoA + oxalate formate + oxalyl-CoA

Thus, the two substrates of this enzyme are formyl-CoA and oxalate, whereas its two products are formate and oxalyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is formyl-CoA:oxalate CoA-transferase. Other names in common use include formyl-coenzyme A transferase, and formyl-CoA oxalate CoA-transferase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1T3Z, 1T4C, 1VGQ, and 1VGR.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Baetz AL, Allison MJ (1990). "Purification and characterization of formyl-coenzyme A transferase from Oxalobacter formigenes". J. Bacteriol. 172: 3537&ndash, 40. PMID 2361939.
  • Sidhu H, Ogden SD, Lung HY, Luttge BG, Baetz AL, Peck AB (1997). "DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes". J. Bacteriol. 179: 3378&ndash, 81. PMID 9150242.

External links

The CAS registry number for this enzyme class is 128826-27-7.