Difference between revisions of "Factor XIII"

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[[Category:Coagulation system]]
 
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[[Category:EC 2.3.2]]

Revision as of 10:26, 20 August 2008

Factor XIII crosslinks fibrin
coagulation factor XIII, A1 polypeptide
Identifiers
SymbolF13A1
Alt. symbolsF13A
Entrez2162
HUGO3531
OMIM134570
RefSeqNM_000129
UniProtP00488
Other data
LocusChr. 6 p24.2-p23
coagulation factor XIII, B polypeptide
Identifiers
SymbolF13B
Entrez2165
HUGO3534
OMIM134580
RefSeqNM_001994
UniProtP05160
Other data
LocusChr. 1 q31-q32.1

WikiDoc Resources for Factor XIII

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Articles on Factor XIII in N Eng J Med, Lancet, BMJ

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Definitions

Definitions of Factor XIII

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Factor XIII en Espanol

Factor XIII en Francais

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Factor XIII in the Marketplace

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Experimental / Informatics

List of terms related to Factor XIII

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Factor XIII or fibrin stabilizing factor is an enzyme (EC 2.3.2.13) of the blood coagulation system that crosslinks fibrin. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor.

FXIII is known also as Laki-Lorand factor, after the scientists who first proposed its existence in 1948.[1] A 2005 conference recommended standardization of nomenclature.[2]

Genetics

Zymogene factor XIII is a 320000 Mr glycoprotein tetramer consisting of twice two subunits (2 A and 2 B),[2] the genes for which are on different chromosomes:

  • A subunit (6p25-p24). The transglutaminase part; this adds an alkyl group to the nitrogen on a glutamine residue, which binds in turn with a lysine on the other chain. The molecular weight of the A chain is approximately 83000.
  • B subunit (1q31-q32.1). This has no clear enzymatic activity, and may serve as a carrier for the A subunit. The molecular weight of the B chain is approximately 76500.

Physiology

Typical concentrations of FXIII in plasma is 10 μg/ml (2A2B heterodimer), while the concentration of free B chain is 22 μg/ml. FXIII has a long half life, ranging from 5-9 days. It is present in plasma, platelets, and monocytes, as well as macrophages and bone marrow precursors of these cell types.[2]

A clot that has not been stabilized by FXIIIa is soluble in 5 mol/L urea, while a stabilized clot is resistant to this phenomenon.[1]

Diagnostic use

Factor XIII levels are not measured routinely, but may be considered in patients with an unexplained bleeding tendency. As the enzyme is quite specific for monocytes and macrophages, determination of the presence of factor XIII may be used to identify and classify malignant diseases involving these cells.[2]

See also

References

  1. 1.0 1.1 Laki K, Lorand L. On the solubility of fibrin clots. Science 1948;108:280.
  2. 2.0 2.1 2.2 2.3 "Factor XIII: recommended terms and abbreviations". J Thromb Haemost. PMID 16938124.

External links

Cost Effectiveness of Factor XIII

| group5 = Clinical Trials Involving Factor XIII | list5 = Ongoing Trials on Factor XIII at Clinical Trials.govTrial results on Factor XIIIClinical Trials on Factor XIII at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Factor XIII | list6 = US National Guidelines Clearinghouse on Factor XIIINICE Guidance on Factor XIIINHS PRODIGY GuidanceFDA on Factor XIIICDC on Factor XIII


| group7 = Textbook Information on Factor XIII | list7 = Books and Textbook Information on Factor XIII


| group8 = Pharmacology Resources on Factor XIII | list8 = AND (Dose)}} Dosing of Factor XIIIAND (drug interactions)}} Drug interactions with Factor XIIIAND (side effects)}} Side effects of Factor XIIIAND (Allergy)}} Allergic reactions to Factor XIIIAND (overdose)}} Overdose information on Factor XIIIAND (carcinogenicity)}} Carcinogenicity information on Factor XIIIAND (pregnancy)}} Factor XIII in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Factor XIII


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Factor XIII | list9 = AND (pharmacogenomics)}} Genetics of Factor XIIIAND (pharmacogenomics)}} Pharmacogenomics of Factor XIIIAND (proteomics)}} Proteomics of Factor XIII


| group10 = Newstories on Factor XIII | list10 = Factor XIII in the newsBe alerted to news on Factor XIIINews trends on Factor XIII


| group11 = Commentary on Factor XIII | list11 = Blogs on Factor XIII

| group12 = Patient Resources on Factor XIII | list12 = Patient resources on Factor XIIIDiscussion groups on Factor XIIIPatient Handouts on Factor XIIIDirections to Hospitals Treating Factor XIIIRisk calculators and risk factors for Factor XIII


| group13 = Healthcare Provider Resources on Factor XIII | list13 = Symptoms of Factor XIIICauses & Risk Factors for Factor XIIIDiagnostic studies for Factor XIIITreatment of Factor XIII

| group14 = Continuing Medical Education (CME) Programs on Factor XIII | list14 = CME Programs on Factor XIII

| group15 = International Resources on Factor XIII | list15 = Factor XIII en EspanolFactor XIII en Francais

| group16 = Business Resources on Factor XIII | list16 = Factor XIII in the MarketplacePatents on Factor XIII

| group17 = Informatics Resources on Factor XIII | list17 = List of terms related to Factor XIII


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de:Fibrinstabilisierender Faktor sv:Faktor XIII



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