CCL11

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chemokine (C-C motif) ligand 11
Identifiers
SymbolCCL11
Alt. symbolsSCYA11, eotaxin
Entrez6356
HUGO10610
OMIM601156
PDB1EOT
RefSeqNM_002986
UniProtP51671
Other data
LocusChr. 17 q11.2-q21.2

Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.[1][2] The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2,[3] CCR3[4] and CCR5.[3] However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. [5] The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.[6][4]


References

  1. Ponath et al. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J. Clin. Invest. 1996, 97:604-612
  2. Garcia-Zepeda et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat. Med. 1996, 2:449-456
  3. 3.0 3.1 Ogilvie et al. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood. 2001, 97:1920-4
  4. 4.0 4.1 Kitaura et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J. Biol. Chem. 1996, 271:7725-7730.
  5. Baggiolini et al. Annual Review of Immunology. 1997. 15:675-705.
  6. Hein et al. Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene. Biochem. Biophys. Res. Commun., 1997 237: 537-542.



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