Difference between revisions of "CCL11"

Jump to: navigation, search
m (Robot: Automated text replacement (-(?ms)^(.*)$ +\1 {{WikiDoc Sources}}))
(Clinical significance)
Line 1: Line 1:
{{protein
+
{{Infobox_gene}}
| Name = chemokine (C-C motif) ligand 11
+
'''C-C motif chemokine 11''' also known as '''eosinophil chemotactic protein''' and '''eotaxin-1''' is a [[protein]] that in humans is encoded by the '''CCL11''' [[gene]]. This gene is encoded on three [[exon]]s and is located on [[chromosome 17]].<ref name="pmid8631813"/><ref name="pmid9299399">{{cite journal | vauthors = Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J | title = Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene | journal = Biochemical and Biophysical Research Communications | volume = 237 | issue = 3 | pages = 537–42 | date = Aug 1997 | pmid = 9299399 | doi = 10.1006/bbrc.1997.7169 }}</ref>
| caption =  
 
| image =  
 
| width =  
 
| HGNCid = 10610
 
| Symbol = CCL11
 
| AltSymbols = SCYA11, eotaxin
 
| EntrezGene = 6356
 
| OMIM = 601156
 
| RefSeq = NM_002986
 
| UniProt = P51671
 
| PDB = 1EOT
 
| ECnumber =  
 
| Chromosome = 17
 
| Arm = q
 
| Band = 11.2
 
| LocusSupplementaryData = -q21.2
 
}}
 
  
'''Chemokine (C-C motif) ligand 11''' (CCL11) is a small [[cytokine]] belonging to the CC [[chemokine]] family that is also known as eotaxin-1. CCL11 selectively recruits [[eosinophil]]s by inducing their [[chemotaxis]], and therefore, is implicated in [[allergic]] responses.<ref>Ponath et al. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J. Clin. Invest. 1996, 97:604-612</ref><ref>Garcia-Zepeda et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat. Med. 1996, 2:449-456</ref>  The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a [[chemokine receptor]].  Chemokine receptors for which CCL11 is a [[ligand]] include [[CC chemokine receptors#CCR2|CCR2]],<ref name =ogilvie>Ogilvie et al. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood. 2001, 97:1920-4</ref> [[CC chemokine receptors#CCR3|CCR3]]<ref name =kitaura>Kitaura et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J. Biol. Chem. 1996, 271:7725-7730.</ref> and [[CC chemokine receptors#CCR5|CCR5]].<ref name =ogilvie/>  However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. <ref name =Baggiolini>Baggiolini et al. Annual Review of Immunology. 1997. 15:675-705.</ref> The [[gene]] for human CCL11 (''scya11'') is encoded on three [[exon]]s and is located on [[chromosome 17]].<ref>Hein et al. Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene. Biochem. Biophys. Res. Commun., 1997 237: 537-542.</ref><ref name =kitaura/>
+
== Function ==
  
 +
CCL11 is a small [[cytokine]] belonging to the CC [[chemokine]] family. CCL11 selectively recruits [[eosinophil]]s by inducing their [[chemotaxis]], and therefore, is implicated in [[allergic]] responses.<ref name="pmid7509365">{{cite journal | vauthors = Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ | title = Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation | journal = The Journal of Experimental Medicine | volume = 179 | issue = 3 | pages = 881–7 | date = Mar 1994 | pmid = 7509365 | pmc = 2191401 | doi = 10.1084/jem.179.3.881 }}</ref><ref name="pmid8609214">{{cite journal | vauthors = Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR | title = Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils | journal = The Journal of Clinical Investigation | volume = 97 | issue = 3 | pages = 604–12 | date = Feb 1996 | pmid = 8609214 | pmc = 507095 | doi = 10.1172/JCI118456 }}</ref><ref name="pmid8597956">{{cite journal | vauthors = Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD | title = Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia | journal = Nature Medicine | volume = 2 | issue = 4 | pages = 449–56 | date = Apr 1996 | pmid = 8597956 | doi = 10.1038/nm0496-449 }}</ref> The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a [[chemokine receptor]].  Chemokine receptors for which CCL11 is a [[ligand]] include [[CC chemokine receptors#CCR2|CCR2]],<ref name="pmid11264152">{{cite journal | vauthors = Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M | title = Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5 | journal = Blood | volume = 97 | issue = 7 | pages = 1920–4 | date = Apr 2001 | pmid = 11264152 | doi = 10.1182/blood.V97.7.1920 }}</ref> [[CC chemokine receptors#CCR3|CCR3]]<ref name="pmid8631813">{{cite journal | vauthors = Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O | title = Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3 | journal = The Journal of Biological Chemistry | volume = 271 | issue = 13 | pages = 7725–30 | date = Mar 1996 | pmid = 8631813 | doi = 10.1074/jbc.271.13.7725 }}</ref> and [[CC chemokine receptors#CCR5|CCR5]].<ref name = "pmid11264152"/>  However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on [[neutrophil]]s and [[monocyte]]s, which do not express CCR3.<ref name="pmid9143704">{{cite journal | vauthors = Baggiolini M, Dewald B, Moser B | title = Human chemokines: an update | journal = Annual Review of Immunology | volume = 15 | issue =  | pages = 675–705 | year = 1997 | pmid = 9143704 | doi = 10.1146/annurev.immunol.15.1.675 }}</ref>
  
==References==
+
== Clinical significance ==
<references/>
 
  
 +
Increased CCL11 levels in blood plasma are associated with aging in mice and humans.<ref name="pmid21886162">{{cite journal | vauthors = Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T | title = The ageing systemic milieu negatively regulates neurogenesis and cognitive function | journal = Nature | volume = 477 | issue = 7362 | pages = 90–4 | date = Sep 2011 | pmid = 21886162 | pmc = 3170097 | doi = 10.1038/nature10357 }}</ref>  Additionally, it has been demonstrated that exposing young mice to CCL11 or the blood plasma of older mice decreases their [[neurogenesis]] and cognitive performance on behavioural tasks thought to be dependent on neurogenesis in the [[hippocampus]].<ref name="pmid21886162" />
  
{{Template:Chemokines}}
+
Higher plasma concentrations of CCL11 have been found in current [[cannabis]] users compared to past users and those who had never used.  CCL11 has also been found in higher concentrations in people suffering from schizophrenia; cannabis is a known trigger of [[schizophrenia]].<ref name="pmid23820464">{{cite journal | vauthors = Fernandez-Egea E, Scoriels L, Theegala S, Giro M, Ozanne SE, Burling K, Jones PB | title = Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | volume = 46 | issue =  | pages = 25–8 | date = Oct 2013 | pmid = 23820464 | doi = 10.1016/j.pnpbp.2013.06.011 }}</ref>
  
{{protein-stub}}
+
It's also a biomarker for [[Chronic traumatic encephalopathy|CTE or punch-drunk syndrome]]<ref>https://www.laboratoryequipment.com/news/2017/09/biomarker-may-distinguish-between-cte-alzheimers-during-life</ref>
[[category:cytokines]]
+
 
{{WikiDoc Help Menu}}
+
A 2016 study by the Department of Urology, Hanyang University College of Medicine, Seoul, Korea noted that CCL11 may be a good indicator for Benign Prostatic Hyperplasia.<ref>https://synapse.koreamed.org/DOIx.php?id=10.14777/uti.2016.11.3.103&vmode=PUBREADER#!po=2.00000</ref>
{{WikiDoc Sources}}
+
 
 +
== References ==
 +
{{Reflist|2}}
 +
 
 +
==External links==
 +
* {{UCSC gene info|CCL11}}
 +
 
 +
== Further reading ==
 +
{{refbegin | 2}}
 +
* {{cite journal | vauthors = Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD | title = Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia | journal = Nature Medicine | volume = 2 | issue = 4 | pages = 449–56 | date = Apr 1996 | pmid = 8597956 | doi = 10.1038/nm0496-449 }}
 +
* {{cite journal | vauthors = Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR | title = Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils | journal = The Journal of Clinical Investigation | volume = 97 | issue = 3 | pages = 604–12 | date = Feb 1996 | pmid = 8609214 | pmc = 507095 | doi = 10.1172/JCI118456 }}
 +
* {{cite journal | vauthors = Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O | title = Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3 | journal = The Journal of Biological Chemistry | volume = 271 | issue = 13 | pages = 7725–30 | date = Mar 1996 | pmid = 8631813 | doi = 10.1074/jbc.271.13.7725 }}
 +
* {{cite journal | vauthors = Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS | title = Cloning, expression, and characterization of the human eosinophil eotaxin receptor | journal = The Journal of Experimental Medicine | volume = 183 | issue = 5 | pages = 2349–54 | date = May 1996 | pmid = 8642344 | pmc = 2192548 | doi = 10.1084/jem.183.5.2349 }}
 +
* {{cite journal | vauthors = Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J | title = The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates | journal = Cell | volume = 85 | issue = 7 | pages = 1135–48 | date = Jun 1996 | pmid = 8674119 | doi = 10.1016/S0092-8674(00)81313-6 }}
 +
* {{cite journal | vauthors = Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR | title = Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils | journal = The Journal of Experimental Medicine | volume = 183 | issue = 6 | pages = 2437–48 | date = Jun 1996 | pmid = 8676064 | pmc = 2192612 | doi = 10.1084/jem.183.6.2437 }}
 +
* {{cite journal | vauthors = Bartels J, Schlüter C, Richter E, Noso N, Kulke R, Christophers E, Schröder JM | title = Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants | journal = Biochemical and Biophysical Research Communications | volume = 225 | issue = 3 | pages = 1045–51 | date = Aug 1996 | pmid = 8780731 | doi = 10.1006/bbrc.1996.1292 }}
 +
* {{cite journal | vauthors = Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, Sarafi MN, Morton CC, Luster AD | title = Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine | journal = Genomics | volume = 41 | issue = 3 | pages = 471–6 | date = May 1997 | pmid = 9169149 | doi = 10.1006/geno.1997.4656 }}
 +
* {{cite journal | vauthors = Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J | title = Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene | journal = Biochemical and Biophysical Research Communications | volume = 237 | issue = 3 | pages = 537–42 | date = Aug 1997 | pmid = 9299399 | doi = 10.1006/bbrc.1997.7169 }}
 +
* {{cite journal | vauthors = Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ | title = Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32078–83 | date = Dec 1997 | pmid = 9405404 | doi = 10.1074/jbc.272.51.32078 }}
 +
* {{cite journal | vauthors = Rubbert A, Combadiere C, Ostrowski M, Arthos J, Dybul M, Machado E, Cohn MA, Hoxie JA, Murphy PM, Fauci AS, Weissman D | title = Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry | journal = Journal of Immunology | volume = 160 | issue = 8 | pages = 3933–41 | date = Apr 1998 | pmid = 9558100 | doi =  }}
 +
* {{cite journal | vauthors = Noso N, Bartels J, Mallet AI, Mochizuki M, Christophers E, Schröder JM | title = Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts | journal = European Journal of Biochemistry / FEBS | volume = 253 | issue = 1 | pages = 114–22 | date = Apr 1998 | pmid = 9578468 | doi = 10.1046/j.1432-1327.1998.2530114.x }}
 +
* {{cite journal | vauthors = Crump MP, Rajarathnam K, Kim KS, Clark-Lewis I, Sykes BD | title = Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation | journal = The Journal of Biological Chemistry | volume = 273 | issue = 35 | pages = 22471–9 | date = Aug 1998 | pmid = 9712872 | doi = 10.1074/jbc.273.35.22471 }}
 +
* {{cite journal | vauthors = Sabroe I, Hartnell A, Jopling LA, Bel S, Ponath PD, Pease JE, Collins PD, Williams TJ | title = Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways | journal = Journal of Immunology | volume = 162 | issue = 5 | pages = 2946–55 | date = Mar 1999 | pmid = 10072545 | doi =  }}
 +
* {{cite journal | vauthors = Jinquan T, Quan S, Feili G, Larsen CG, Thestrup-Pedersen K | title = Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 | journal = Journal of Immunology | volume = 162 | issue = 7 | pages = 4285–92 | date = Apr 1999 | pmid = 10201960 | doi =  }}
 +
* {{cite journal | vauthors = Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD | title = Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS | journal = Journal of Immunology | volume = 163 | issue = 3 | pages = 1636–46 | date = Aug 1999 | pmid = 10415069 | doi =  }}
 +
* {{cite journal | vauthors = Blanpain C, Migeotte I, Lee B, Vakili J, Doranz BJ, Govaerts C, Vassart G, Doms RW, Parmentier M | title = CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist | journal = Blood | volume = 94 | issue = 6 | pages = 1899–905 | date = Sep 1999 | pmid = 10477718 | doi =  }}
 +
* {{cite journal | vauthors = Zhang J, Lathbury LJ, Salamonsen LA | title = Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium | journal = Biology of Reproduction | volume = 62 | issue = 2 | pages = 404–11 | date = Feb 2000 | pmid = 10642580 | doi = 10.1095/biolreprod62.2.404 }}
 +
* {{cite journal | vauthors = Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, Alam R | title = Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases | journal = Blood | volume = 95 | issue = 6 | pages = 1911–7 | date = Mar 2000 | pmid = 10706854 | doi =  }}
 +
* {{cite journal | vauthors = Huber MA, Kraut N, Addicks T, Peter RU | title = Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation | journal = Biochemical and Biophysical Research Communications | volume = 269 | issue = 2 | pages = 546–52 | date = Mar 2000 | pmid = 10708591 | doi = 10.1006/bbrc.2000.2287 }}
 +
{{refend}}
 +
 
 +
 
 +
{{PDB Gallery|geneid=6356}}
 +
{{Chemokines}}
 +
{{Chemokine receptor modulators}}
 +
 
 +
[[Category:Cytokines]]
 +
[[Category:Aging-related proteins]]

Revision as of 11:10, 2 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromosome 17.[1][2]

Function

CCL11 is a small cytokine belonging to the CC chemokine family. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.[3][4][5] The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2,[6] CCR3[1] and CCR5.[6] However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.[7]

Clinical significance

Increased CCL11 levels in blood plasma are associated with aging in mice and humans.[8] Additionally, it has been demonstrated that exposing young mice to CCL11 or the blood plasma of older mice decreases their neurogenesis and cognitive performance on behavioural tasks thought to be dependent on neurogenesis in the hippocampus.[8]

Higher plasma concentrations of CCL11 have been found in current cannabis users compared to past users and those who had never used. CCL11 has also been found in higher concentrations in people suffering from schizophrenia; cannabis is a known trigger of schizophrenia.[9]

It's also a biomarker for CTE or punch-drunk syndrome[10]

A 2016 study by the Department of Urology, Hanyang University College of Medicine, Seoul, Korea noted that CCL11 may be a good indicator for Benign Prostatic Hyperplasia.[11]

References

  1. 1.0 1.1 Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
  2. Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
  3. Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (Mar 1994). "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation". The Journal of Experimental Medicine. 179 (3): 881–7. doi:10.1084/jem.179.3.881. PMC 2191401. PMID 7509365.
  4. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.
  5. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956.
  6. 6.0 6.1 Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (Apr 2001). "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5". Blood. 97 (7): 1920–4. doi:10.1182/blood.V97.7.1920. PMID 11264152.
  7. Baggiolini M, Dewald B, Moser B (1997). "Human chemokines: an update". Annual Review of Immunology. 15: 675–705. doi:10.1146/annurev.immunol.15.1.675. PMID 9143704.
  8. 8.0 8.1 Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T (Sep 2011). "The ageing systemic milieu negatively regulates neurogenesis and cognitive function". Nature. 477 (7362): 90–4. doi:10.1038/nature10357. PMC 3170097. PMID 21886162.
  9. Fernandez-Egea E, Scoriels L, Theegala S, Giro M, Ozanne SE, Burling K, Jones PB (Oct 2013). "Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 46: 25–8. doi:10.1016/j.pnpbp.2013.06.011. PMID 23820464.
  10. https://www.laboratoryequipment.com/news/2017/09/biomarker-may-distinguish-between-cte-alzheimers-during-life
  11. https://synapse.koreamed.org/DOIx.php?id=10.14777/uti.2016.11.3.103&vmode=PUBREADER#!po=2.00000

External links

Further reading

  • Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956.
  • Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.
  • Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
  • Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". The Journal of Experimental Medicine. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
  • Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J (Jun 1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates". Cell. 85 (7): 1135–48. doi:10.1016/S0092-8674(00)81313-6. PMID 8674119.
  • Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR (Jun 1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". The Journal of Experimental Medicine. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.
  • Bartels J, Schlüter C, Richter E, Noso N, Kulke R, Christophers E, Schröder JM (Aug 1996). "Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants". Biochemical and Biophysical Research Communications. 225 (3): 1045–51. doi:10.1006/bbrc.1996.1292. PMID 8780731.
  • Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, Sarafi MN, Morton CC, Luster AD (May 1997). "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine". Genomics. 41 (3): 471–6. doi:10.1006/geno.1997.4656. PMID 9169149.
  • Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
  • Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Dec 1997). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". The Journal of Biological Chemistry. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
  • Rubbert A, Combadiere C, Ostrowski M, Arthos J, Dybul M, Machado E, Cohn MA, Hoxie JA, Murphy PM, Fauci AS, Weissman D (Apr 1998). "Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry". Journal of Immunology. 160 (8): 3933–41. PMID 9558100.
  • Noso N, Bartels J, Mallet AI, Mochizuki M, Christophers E, Schröder JM (Apr 1998). "Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts". European Journal of Biochemistry / FEBS. 253 (1): 114–22. doi:10.1046/j.1432-1327.1998.2530114.x. PMID 9578468.
  • Crump MP, Rajarathnam K, Kim KS, Clark-Lewis I, Sykes BD (Aug 1998). "Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation". The Journal of Biological Chemistry. 273 (35): 22471–9. doi:10.1074/jbc.273.35.22471. PMID 9712872.
  • Sabroe I, Hartnell A, Jopling LA, Bel S, Ponath PD, Pease JE, Collins PD, Williams TJ (Mar 1999). "Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways". Journal of Immunology. 162 (5): 2946–55. PMID 10072545.
  • Jinquan T, Quan S, Feili G, Larsen CG, Thestrup-Pedersen K (Apr 1999). "Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4". Journal of Immunology. 162 (7): 4285–92. PMID 10201960.
  • Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD (Aug 1999). "Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS". Journal of Immunology. 163 (3): 1636–46. PMID 10415069.
  • Blanpain C, Migeotte I, Lee B, Vakili J, Doranz BJ, Govaerts C, Vassart G, Doms RW, Parmentier M (Sep 1999). "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist". Blood. 94 (6): 1899–905. PMID 10477718.
  • Zhang J, Lathbury LJ, Salamonsen LA (Feb 2000). "Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium". Biology of Reproduction. 62 (2): 404–11. doi:10.1095/biolreprod62.2.404. PMID 10642580.
  • Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, Alam R (Mar 2000). "Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases". Blood. 95 (6): 1911–7. PMID 10706854.
  • Huber MA, Kraut N, Addicks T, Peter RU (Mar 2000). "Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation". Biochemical and Biophysical Research Communications. 269 (2): 546–52. doi:10.1006/bbrc.2000.2287. PMID 10708591.



Linked-in.jpg