Difference between revisions of "CAMK1"

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{{Infobox_gene}}
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'''Calcium/calmodulin-dependent protein kinase type 1''' is an [[enzyme]] that in humans is encoded by the ''CAMK1'' [[gene]].<ref name="pmid7641687">{{cite journal | vauthors = Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR | title = Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase | journal = EMBO J | volume = 14 | issue = 15 | pages = 3679–86 |date=Sep 1995 | pmid = 7641687 | pmc = 394442 | doi = }}</ref><ref name="entrez"/>
| image = PBB_Protein_CAMK1_image.jpg
 
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a06.
 
| PDB = {{PDB2|1a06}}
 
| Name = Calcium/calmodulin-dependent protein kinase I
 
| HGNCid = 1459
 
| Symbol = CAMK1
 
| AltSymbols =; CAMKI; MGC120317; MGC120318
 
| OMIM = 604998
 
| ECnumber = 
 
| Homologene = 74503
 
| MGIid = 1098535
 
| GeneAtlas_image1 = PBB_GE_CAMK1_204392_at_tn.png
 
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004685 |text = calmodulin-dependent protein kinase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
 
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
 
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
 
| Orthologs = {{GNF_Ortholog_box
 
    | Hs_EntrezGene = 8536
 
    | Hs_Ensembl = ENSG00000134072
 
    | Hs_RefseqProtein = NP_003647
 
    | Hs_RefseqmRNA = NM_003656
 
    | Hs_GenLoc_db = 
 
    | Hs_GenLoc_chr = 3
 
    | Hs_GenLoc_start = 9774032
 
    | Hs_GenLoc_end = 9786661
 
    | Hs_Uniprot = Q14012
 
    | Mm_EntrezGene = 52163
 
    | Mm_Ensembl = ENSMUSG00000030272
 
    | Mm_RefseqmRNA = NM_133926
 
    | Mm_RefseqProtein = NP_598687
 
    | Mm_GenLoc_db = 
 
    | Mm_GenLoc_chr = 6
 
    | Mm_GenLoc_start = 113299901
 
    | Mm_GenLoc_end = 113309699
 
    | Mm_Uniprot = Q3TDH8
 
  }}
 
}}
 
'''Calcium/calmodulin-dependent protein kinase I''', also known as '''CAMK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536| accessdate = }}</ref>
 
  
 
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{{PBB_Summary
 
{{PBB_Summary
 
| section_title =  
 
| section_title =  
| summary_text = Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade.  Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.<ref name="entrez">{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536| accessdate = }}</ref>
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| summary_text = Calcium/calmodulin-dependent [[protein kinase]] I is [[gene expression|expressed]] in many [[tissue (biology)|tissues]] and is a component of a [[calmodulin]]-dependent protein kinase cascade.  Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the [[phosphorylation]] and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.<ref name="entrez">{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536| accessdate = }}</ref>
 
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==References==
 
==References==
 
{{reflist}}
 
{{reflist}}
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==Further reading==
 
==Further reading==
 
{{refbegin | 2}}
 
{{refbegin | 2}}
 
{{PBB_Further_reading  
 
{{PBB_Further_reading  
 
| citations =  
 
| citations =  
*{{cite journal  | author=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976-81 |year= 1992 |pmid= 1375933 |doi=  }}
+
*{{cite journal  | vauthors=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976–81 |year= 1992 |pmid= 1375933 |doi=  }}
*{{cite journal  | author=Yokokura H, Picciotto MR, Nairn AC, Hidaka H |title=The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains. |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23851-9 |year= 1995 |pmid= 7559563 |doi=  }}
+
*{{cite journal  | vauthors=Yokokura H, Picciotto MR, Nairn AC, Hidaka H |title=The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23851–9 |year= 1995 |pmid= 7559563 |doi=10.1074/jbc.270.40.23851 }}
*{{cite journal  | author=Haribabu B, Hook SS, Selbert MA, ''et al.'' |title=Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. |journal=EMBO J. |volume=14 |issue= 15 |pages= 3679-86 |year= 1995 |pmid= 7641687 |doi=  }}
+
*{{cite journal  | vauthors=Liu F, Thompson MA, Wagner S |title=Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6714–20 |year= 1993 |pmid= 8384217 |doi=  |display-authors=etal}}
*{{cite journal  | author=Liu F, Thompson MA, Wagner S, ''et al.'' |title=Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation. |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6714-20 |year= 1993 |pmid= 8384217 |doi=  }}
+
*{{cite journal  | vauthors=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235–40 |year= 1998 |pmid= 9395448 |doi=10.1074/jbc.272.50.31235 }}
*{{cite journal  | author=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235-40 |year= 1998 |pmid= 9395448 |doi=  }}
+
*{{cite journal  | vauthors=Hsu LS, Tsou AP, Chi CW |title=Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biomed. Sci. |volume=5 |issue= 2 |pages= 141–9 |year= 1998 |pmid= 9662074 |doi=  10.1007/bf02258368|display-authors=etal}}
*{{cite journal  | author=Hsu LS, Tsou AP, Chi CW, ''et al.'' |title=Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biomed. Sci. |volume=5 |issue= 2 |pages= 141-9 |year= 1998 |pmid= 9662074 |doi=  }}
+
*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473–81 |year= 1998 |pmid= 9705275 |doi=10.1074/jbc.273.34.21473 }}
*{{cite journal  | author=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473-81 |year= 1998 |pmid= 9705275 |doi= }}
+
*{{cite journal  | vauthors=Anderson KA, Means RL, Huang QH |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880–9 |year= 1998 |pmid= 9822657 |doi=10.1074/jbc.273.48.31880  |display-authors=etal}}
*{{cite journal  | author=Anderson KA, Means RL, Huang QH, ''et al.'' |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880-9 |year= 1998 |pmid= 9822657 |doi= }}
+
*{{cite journal  | vauthors=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086–93 |year= 1999 |pmid= 10187789 |doi=10.1074/jbc.274.15.10086  }}
*{{cite journal  | author=Matsushita M, Nairn AC |title=Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10086-93 |year= 1999 |pmid= 10187789 |doi= }}
+
*{{cite journal  | vauthors=Hayashi Y, Nishio M, Naito Y |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597–602 |year= 1999 |pmid= 10400690 |doi=10.1074/jbc.274.29.20597  |display-authors=etal}}
*{{cite journal  | author=Hayashi Y, Nishio M, Naito Y, ''et al.'' |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597-602 |year= 1999 |pmid= 10400690 |doi=  }}
+
*{{cite journal  | vauthors=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles |journal=Neuron |volume=24 |issue= 2 |pages= 377–87 |year= 1999 |pmid= 10571231 |doi=10.1016/S0896-6273(00)80851-X }}
*{{cite journal  | author=Hosaka M, Hammer RE, Südhof TC |title=A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. |journal=Neuron |volume=24 |issue= 2 |pages= 377-87 |year= 1999 |pmid= 10571231 |doi= }}
+
*{{cite journal  | vauthors=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139–43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200 }}
*{{cite journal  | author=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139-43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200 }}
+
*{{cite journal  | vauthors=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation |journal=Nature |volume=408 |issue= 6808 |pages= 106–11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593 |pmc=4459600 }}
*{{cite journal  | author=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. |journal=Nature |volume=408 |issue= 6808 |pages= 106-11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593 }}
+
*{{cite journal  | vauthors=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497  | pmc=18930 }}
*{{cite journal  | author=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400-5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497 }}
+
*{{cite journal  | vauthors=Hsu LS, Chen GD, Lee LS |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113–23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200 |display-authors=etal}}
*{{cite journal  | author=Hsu LS, Chen GD, Lee LS, ''et al.'' |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113-23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200 }}
+
*{{cite journal  | vauthors=Condon JC, Pezzi V, Drummond BM |title=Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase |journal=Endocrinology |volume=143 |issue= 9 |pages= 3651–7 |year= 2002 |pmid= 12193581 |doi=10.1210/en.2001-211359  |display-authors=etal}}
*{{cite journal  | author=Condon JC, Pezzi V, Drummond BM, ''et al.'' |title=Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. |journal=Endocrinology |volume=143 |issue= 9 |pages= 3651-7 |year= 2002 |pmid= 12193581 |doi= }}
+
*{{cite journal  | vauthors=Sakurada K, Kato H, Nagumo H |title=Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45473–9 |year= 2003 |pmid= 12237306 |doi= 10.1074/jbc.M206673200 |display-authors=etal}}
*{{cite journal  | author=Sakurada K, Kato H, Nagumo H, ''et al.'' |title=Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45473-9 |year= 2003 |pmid= 12237306 |doi= 10.1074/jbc.M206673200 }}
+
*{{cite journal  | vauthors=Clapperton JA, Martin SR, Smerdon SJ |title=Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism |journal=Biochemistry |volume=41 |issue= 50 |pages= 14669–79 |year= 2003 |pmid= 12475216 |doi=10.1021/bi026660t  |display-authors=etal}}
*{{cite journal  | author=Clapperton JA, Martin SR, Smerdon SJ, ''et al.'' |title=Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. |journal=Biochemistry |volume=41 |issue= 50 |pages= 14669-79 |year= 2003 |pmid= 12475216 |doi=  }}
+
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+
*{{cite journal  | vauthors=Izmailova E, Bertley FM, Huang Q |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 |display-authors=etal}}
*{{cite journal  | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191-7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
 
 
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==External links==
{{WikiDoc Sources}}
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* {{UCSC gene info|CAMK1}}
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{{PDB Gallery|geneid=8536}}
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{{Serine/threonine-specific protein kinases}}
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{{Enzymes}}
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Latest revision as of 11:44, 16 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.[1][2]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[2]

References

  1. Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. PMC 394442. PMID 7641687.
  2. 2.0 2.1 "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

Further reading

External links



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