Difference between revisions of "Bethanechol chloride"

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|drugClass=urinary antispasmodic
 
|drugClass=urinary antispasmodic
 
|indicationType=treatment
 
|indicationType=treatment
|indication=acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention
+
|indication=acute postoperative and postpartum nonobstructive (functional) [[urinary retention]] and for neurogenic atony of the [[urinary bladder]] with retention
|adverseReactions=flushing, abdominal cramps, diarrhea and urgent desire to urinate
+
|adverseReactions=[[flushing]], [[abdominal cramps]], [[diarrhea]] and [[urinary incontinence]]
 
|blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
 
|blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
 
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
 
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
|fdaLIADAdult=treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.
+
|fdaLIADAdult=Treatment of acute postoperative and postpartum nonobstructive (functional) [[urinary retention]] and for neurogenic atony of the [[urinary bladder]] with retention.
 
* Dosage:
 
* Dosage:
 
:* Initial: 5 to 10 mg initially and repeating the same amount at hourly intervals until satisfactory response occurs, or until a maximum of 50 mg has been given.
 
:* Initial: 5 to 10 mg initially and repeating the same amount at hourly intervals until satisfactory response occurs, or until a maximum of 50 mg has been given.
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|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Bethanechol chloride in pediatric patients.
 
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Bethanechol chloride in pediatric patients.
 
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Bethanechol chloride in pediatric patients.
 
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Bethanechol chloride in pediatric patients.
|contraindications=* Hypersensitivity to bethanechol chloride, hyperthyroidism, peptic ulcer, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor instability, coronary artery disease, epilepsy and parkinsonism.
+
|contraindications=* [[Hypersensitivity]] to bethanechol chloride, [[hyperthyroidism]], [[peptic ulcer]], latent or active bronchial [[asthma]], pronounced [[bradycardia]] or [[hypotension]], [[vasomotor instability]], [[coronary artery disease]], [[epilepsy]] and [[parkinsonism]].
  
* Bethanechol chloride should not be employed when the strength or integrity of the gastrointestinal or bladder wall is in question, or in the presence of mechanical obstruction; when increased muscular activity of the gastrointestinal tract or urinary bladder might prove harmful, as following recent urinary bladder surgery, gastrointestinal resection and anastomosis, or when there is possible gastrointestinal obstruction; in bladder neck obstruction, spastic gastrointestinal disturbances, acute inflammatory lesions of the gastrointestinal tract, or peritonitis; or in marked vagotonia.
+
* Bethanechol chloride should not be employed when the strength or integrity of the gastrointestinal or bladder wall is in question, or in the presence of mechanical obstruction; when increased muscular activity of the gastrointestinal tract or urinary bladder might prove harmful, as following recent [[urinary bladder]] surgery, [[gastrointestinal resection]] and anastomosis, or when there is possible gastrointestinal obstruction; in [[bladder neck obstruction]], [[spastic gastrointestinal disturbances]], acute inflammatory lesions of the gastrointestinal tract, or [[peritonitis]]; or in marked [[vagotonia]].
 
|clinicalTrials=Adverse reactions are rare following oral administration of bethanechol chloride, but are more common following subcutaneous injection. Adverse reactions are more likely to occur when dosage is increased.
 
|clinicalTrials=Adverse reactions are rare following oral administration of bethanechol chloride, but are more common following subcutaneous injection. Adverse reactions are more likely to occur when dosage is increased.
  
 
The following adverse reactions have been observed:   
 
The following adverse reactions have been observed:   
* Body as a Whole: malaise
+
* Body as a Whole: [[malaise]]
* Digestive: abdominal cramps or discomfort, colicky pain, nausea and belching, diarrhea, borborygmi, salivation
+
* Digestive: [[abdominal cramps]] or discomfort, [[colicky pain]], [[nausea]] and [[belching]], [[diarrhea]], [[borborygmi]], [[salivation]]
* Renal: urinary urgency
+
* Renal: [[urinary urgency]]
* Nervous System: headache
+
* Nervous System: [[headache]]
* Cardiovascular: a fall in blood pressure with reflex tachycardia, vasomotor response
+
* Cardiovascular: a fall in blood pressure with reflex [[tachycardia]], [[vasomotor response]]
* Skin: flushing producing a feeling of warmth, sensation of heat about the face, sweating
+
* Skin: [[flushing]] producing a feeling of warmth, sensation of heat about the face, [[sweating]]
* Respiratory: bronchial constriction, asthmatic attacks
+
* Respiratory: [[bronchial constriction]], [[asthmatic attacks]]
* Special Senses: lacrimation, miosis
+
* Special Senses: [[lacrimation]], [[miosis]]
  
 
====Causal Relationship Unknown====
 
====Causal Relationship Unknown====
 
The following adverse reactions have been reported, and a causal relationship to therapy with bethanechol chloride has not been established:
 
The following adverse reactions have been reported, and a causal relationship to therapy with bethanechol chloride has not been established:
* Body as a Whole: malaise
+
* Body as a Whole: [[malaise]]
* Nervous System: seizures
+
* Nervous System: [[seizures]]
 
|drugInteractions=Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.
 
|drugInteractions=Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.
 
|FDAPregCat=C
 
|FDAPregCat=C
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|useInReproPotential=Long-term studies in animals have not been performed to evaluate the effects upon fertility of bethanechol chloride.
 
|useInReproPotential=Long-term studies in animals have not been performed to evaluate the effects upon fertility of bethanechol chloride.
 
|administration=Oral
 
|administration=Oral
|overdose=Early signs of overdosage are abdominal discomfort, salivation, flushing of the skin (“hot feeling”), sweating, nausea, and vomiting.
+
|overdose=Early signs of overdosage are [[abdominal discomfort]], [[salivation]], [[flushing]] of the skin (“hot feeling”), [[sweating]], [[nausea and vomiting]].
  
Atropine sulfate is a specific antidote. The recommended dose for adults is 0.6 mg. Repeat doses can be given every two hours, according to clinical response. The recommended dosage in infants and children up to 12 years of age is 0.01 mg/kg (to a maximum single dose of 0.4 mg) repeated every two hours as needed until the desired effect is obtained or adverse effects of atropine preclude further usage. Subcutaneous injection of atropine is preferred except in emergencies when the intravenous route may be employed.
+
[[Atropine sulfate]] is a specific antidote. The recommended dose for adults is 0.6 mg. Repeat doses can be given every two hours, according to clinical response. The recommended dosage in infants and children up to 12 years of age is 0.01 mg/kg (to a maximum single dose of 0.4 mg) repeated every two hours as needed until the desired effect is obtained or adverse effects of atropine preclude further usage. Subcutaneous injection of atropine is preferred except in emergencies when the intravenous route may be employed.
  
 
The oral LD50 of bethanechol chloride is 1510 mg/kg in the mouse.
 
The oral LD50 of bethanechol chloride is 1510 mg/kg in the mouse.
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|nonClinToxic=====Carcinogenesis, Mutagenesis, Impairment of Fertility====
 
|nonClinToxic=====Carcinogenesis, Mutagenesis, Impairment of Fertility====
 
Long-term studies in animals have not been performed to evaluate the effects upon fertility, mutagenic or carcinogenic potential of bethanechol chloride.
 
Long-term studies in animals have not been performed to evaluate the effects upon fertility, mutagenic or carcinogenic potential of bethanechol chloride.
|clinicalStudies=A clinical study (Diokno, A.C.; Lapides, J.; Urol 10: 23-24, July 1977) was conducted on the relative effectiveness of oral and subcutaneous doses of bethanechol chloride on the stretch response of bladder muscle in patients with urinary retention. Results showed that 5 mg of the drug given subcutaneously stimulated a response that was more rapid in onset and of larger magnitude than an oral dose of 50 mg, 100 mg, or 200 mg. All the oral doses, however, had a longer duration of effect than the subcutaneous dose. Although the 50 mg oral dose caused little change in intravesical pressure in this study, this dose has been found in other studies to be clinically effective in the rehabilitation of patients with decompensated bladders.
+
|clinicalStudies=A clinical study (Diokno, A.C.; Lapides, J.; Urol 10: 23-24, July 1977) was conducted on the relative effectiveness of oral and subcutaneous doses of bethanechol chloride on the stretch response of [[bladder muscle]] in patients with urinary retention. Results showed that 5 mg of the drug given subcutaneously stimulated a response that was more rapid in onset and of larger magnitude than an oral dose of 50 mg, 100 mg, or 200 mg. All the oral doses, however, had a longer duration of effect than the subcutaneous dose. Although the 50 mg oral dose caused little change in intravesical pressure in this study, this dose has been found in other studies to be clinically effective in the rehabilitation of patients with decompensated bladders.
|howSupplied=5 mg: White, round, flat-face, beveled edge, scored tablet. Debossed with OP/697 on the scored side and plain on the other side. Available in bottles of 100.
+
|howSupplied=* Bethanechol chloride 5 mg tablet
 +
:* Available in bottles of 100
  
 
* Bethanechol chloride 10 mg tablet
 
* Bethanechol chloride 10 mg tablet
:* Available in bottles of 100.
+
:* Available in bottles of 100
  
Bethanechol chloride 25 mg tablet
+
* Bethanechol chloride 25 mg tablet
:* Available in bottles of 100.
+
:* Available in bottles of 100
  
 
* Bethanechol chloride 50 mg tablet
 
* Bethanechol chloride 50 mg tablet
:* Available in bottles of 100.
+
:* Available in bottles of 100
|storage=Store at 20° to 25°C (68° to 77°F)  
+
|storage=Store at 20° to 25°C (68° to 77°F)
|fdaPatientInfo=Bethanechol chloride should preferably be taken one hour before or two hours after meals to avoid nausea or vomiting. Dizziness, lightheadedness or fainting may occur, especially when getting up from a lying or sitting position.
+
|drugImages=
 +
|fdaPatientInfo=Bethanechol chloride should preferably be taken one hour before or two hours after meals to avoid [[nausea]] or [[vomiting]]. [[Dizziness]], [[lightheadedness]] or [[fainting]] may occur, especially when getting up from a lying or sitting position.
 
|alcohol=Alcohol-Bethanechol chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
 
|alcohol=Alcohol-Bethanechol chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
 +
|brandNames=* Urecholine <ref>{{cite web|url=http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5513ddc8-90c8-4548-8188-5a807465cdc4|title=FDA LABEL: URECHOLINE- bethanechol chloride tablet}}</ref>
 
}}
 
}}
 +
{{LabelImage
 +
|fileName=Bethanechol chloride 5 mg.png
 +
}}
 +
{{LabelImage
 +
|fileName=Bethanechol chloride 10 mg.png
 +
}}
 +
{{LabelImage
 +
|fileName=Bethanechol chloride 25 mg.png
 +
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 +
{{LabelImage
 +
|fileName=Bethanechol chloride 50 mg.png
 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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Latest revision as of 15:24, 8 August 2015

Bethanechol chloride
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gloria Picoy [2]

Disclaimer

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Overview

Bethanechol chloride is an urinary antispasmodic that is FDA approved for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Common adverse reactions include flushing, abdominal cramps, diarrhea and urinary incontinence.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.

  • Dosage:
  • Initial: 5 to 10 mg initially and repeating the same amount at hourly intervals until satisfactory response occurs, or until a maximum of 50 mg has been given.
  • Usual dose range: 10 to 50 mg three or four times a day.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Bethanechol chloride in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Bethanechol chloride in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Not FDA approved in pediatric patients

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Bethanechol chloride in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Bethanechol chloride in pediatric patients.

Contraindications

Warnings

There is limited information regarding Bethanechol chloride Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

Adverse reactions are rare following oral administration of bethanechol chloride, but are more common following subcutaneous injection. Adverse reactions are more likely to occur when dosage is increased.

The following adverse reactions have been observed:

Causal Relationship Unknown

The following adverse reactions have been reported, and a causal relationship to therapy with bethanechol chloride has not been established:

Postmarketing Experience

There is limited information regarding Bethanechol chloride Postmarketing Experience in the drug label.

Drug Interactions

Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): C Animal reproduction studies have not been conducted with bethanechol chloride. It is also not known whether bethanechol chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Bethanechol chloride should be given to a pregnant woman only if clearly needed.
Pregnancy Category (AUS): B2 There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Bethanechol chloride in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Bethanechol chloride during labor and delivery.

Nursing Mothers

It is not known whether this drug is secreted in human milk. Because many drugs are secreted in human milk and because of the potential for serious adverse reactions from bethanechol chloride in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatic Use

There is no FDA guidance on the use of Bethanechol chloride in geriatric settings.

Gender

There is no FDA guidance on the use of Bethanechol chloride with respect to specific gender populations.

Race

There is no FDA guidance on the use of Bethanechol chloride with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Bethanechol chloride in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Bethanechol chloride in patients with hepatic impairment.

Females of Reproductive Potential and Males

Long-term studies in animals have not been performed to evaluate the effects upon fertility of bethanechol chloride.

Immunocompromised Patients

There is no FDA guidance one the use of Bethanechol chloride in patients who are immunocompromised.

Administration and Monitoring

Administration

Oral

Monitoring

There is limited information regarding Bethanechol chloride Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Bethanechol chloride and IV administrations.

Overdosage

Early signs of overdosage are abdominal discomfort, salivation, flushing of the skin (“hot feeling”), sweating, nausea and vomiting.

Atropine sulfate is a specific antidote. The recommended dose for adults is 0.6 mg. Repeat doses can be given every two hours, according to clinical response. The recommended dosage in infants and children up to 12 years of age is 0.01 mg/kg (to a maximum single dose of 0.4 mg) repeated every two hours as needed until the desired effect is obtained or adverse effects of atropine preclude further usage. Subcutaneous injection of atropine is preferred except in emergencies when the intravenous route may be employed.

The oral LD50 of bethanechol chloride is 1510 mg/kg in the mouse.

Pharmacology

Bethanechol chloride structure.png
Bethanechol chloride
Systematic (IUPAC) name
2-(Carbamoyloxy)-N,N,N-trimethylpropan-1-aminium
Identifiers
CAS number 674-38-4
ATC code N07AB02
PubChem 2370
DrugBank DB01019
Chemical data
Formula C7H17N2O2 
Mol. mass 161.221 g/mol
SMILES eMolecules & PubChem
Synonyms 2-[(aminocarbonyl)oxy]- N,N,N-trimethyl- 1-propanaminium
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status
Routes Oral, subcutaneous

Mechanism of Action

Bethanechol chloride acts principally by producing the effects of stimulation of the para- sympathetic nervous system. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone and often restores impaired rhythmic peristalsis.

Stimulation of the parasympathetic nervous system releases acetylcholine at the nerve endings. When spontaneous stimulation is reduced and therapeutic intervention is required, acetylcholine can be given, but it is rapidly hydrolyzed by cholinesterase and its effects are transient. Bethan- echol chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetylcholine.

Structure

It is designated chemically as 2-[(aminocarbonyl)oxy]-N, N, N-trimethyl-1-propanaminium chloride. Its structural formula is:

Bethanechol chloride structural formula.png

Pharmacodynamics

Because of the selective action of bethanechol chloride, nicotinic symptoms of cholinergic stimulation are usually absent or minimal when orally or subcutaneously administered in therapeutic doses, while muscarinic effects are prominent. Muscarinic effects usually occur within 5 to 15 minutes after subcutaneous injection, reach a maximum in 15 to 30 minutes, and disappear within two hours. Doses that stimulate micturition and defecation and increase peristalsis do not ordinarily stimulate ganglia or voluntary muscles. Therapeutic test doses in normal human subjects have little effect on heart rate, blood pressure or peripheral circulation.

Bethanechol chloride does not cross the blood-brain barrier because of its charged quaternary amine moiety. The metabolic rate and mode of excretion of the drug have not been elucidated.

Pharmacokinetics

Effects on the Gl and urinary tracts sometimes appear within 30 minutes after oral administration of bethanechol chloride, but more often 60 to 90 minutes are required to reach maximum effec- tiveness. Following oral administration, the usual duration of action of bethanechol chloride is one hour, although large doses (300 to 400 mg) have been reported to produce effects for up to six hours. Subcutaneous injection produces a more intense action on bladder muscle than does oral administration of the drug.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies in animals have not been performed to evaluate the effects upon fertility, mutagenic or carcinogenic potential of bethanechol chloride.

Clinical Studies

A clinical study (Diokno, A.C.; Lapides, J.; Urol 10: 23-24, July 1977) was conducted on the relative effectiveness of oral and subcutaneous doses of bethanechol chloride on the stretch response of bladder muscle in patients with urinary retention. Results showed that 5 mg of the drug given subcutaneously stimulated a response that was more rapid in onset and of larger magnitude than an oral dose of 50 mg, 100 mg, or 200 mg. All the oral doses, however, had a longer duration of effect than the subcutaneous dose. Although the 50 mg oral dose caused little change in intravesical pressure in this study, this dose has been found in other studies to be clinically effective in the rehabilitation of patients with decompensated bladders.

How Supplied

  • Bethanechol chloride 5 mg tablet
  • Available in bottles of 100
  • Bethanechol chloride 10 mg tablet
  • Available in bottles of 100
  • Bethanechol chloride 25 mg tablet
  • Available in bottles of 100
  • Bethanechol chloride 50 mg tablet
  • Available in bottles of 100

Storage

Store at 20° to 25°C (68° to 77°F)

Images

Drug Images

BETHANECHOL CHLORIDE NDC 604290341.jpg

Drug Name: BETHANECHOL CHLORIDE
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: EP119
Dosage: 10 mg
Color(s): White
Shape: Round
Size (mm): 8
Score: 2
NDC:604290341

Drug Label Author: Golden State Medical Supply, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
BETHANECHOL CHLORIDE NDC 604290342.jpg

Drug Name: BETHANECHOL CHLORIDE
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: EP120
Dosage: 25 mg
Color(s): White
Shape: Round
Size (mm): 9
Score: 2
NDC:604290342

Drug Label Author: Golden State Medical Supply, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 01159511.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: 951
Dosage: 5 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:01159511

Drug Label Author: Global Pharmaceuticals, Division of Impax Laboratories, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 08320510.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): Bethanechol Chloride[Bethanechol]
Imprint: BCL;5;832
Dosage: 5 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:08320510

Drug Label Author: Upsher-Smith Laboratories, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 08320511.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): Bethanechol Chloride[Bethanechol]
Imprint: BCL;10;832
Dosage: 10 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:08320511

Drug Label Author: Upsher-Smith Laboratories, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 08320512.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): Bethanechol Chloride[Bethanechol]
Imprint: BCL;25;832
Dosage: 25 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:08320512

Drug Label Author: Upsher-Smith Laboratories, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 09046176.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: AN;571
Dosage: 5 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:09046176

Drug Label Author: Major Pharmaceuticals

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 09046178.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: AN;573
Dosage: 25 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:09046178

Drug Label Author: Major Pharmaceuticals

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 422910169.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: AN;573
Dosage: 25 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:422910169

Drug Label Author: AvKARE, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 501110323.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: PLIVA;323
Dosage: 5 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:501110323

Drug Label Author: Pliva Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 501110324.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: PLIVA;324
Dosage: 10 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:501110324

Drug Label Author: Pliva Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 501110325.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: PLIVA;325
Dosage: 25 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:501110325

Drug Label Author: Pliva Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 501110326.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: PLIVA;326
Dosage: 50 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:501110326

Drug Label Author: Pliva Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 651620571.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: AN;571
Dosage: 5 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:651620571

Drug Label Author: Amneal Pharmaceuticals

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 651620572.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: AN;572
Dosage: 10 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:651620572

Drug Label Author: Amneal Pharmaceuticals

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 651620573.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: AN;573
Dosage: 25 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:651620573

Drug Label Author: Amneal Pharmaceuticals

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol Chloride NDC 651620574.jpg

Drug Name: Bethanechol Chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: AN;574
Dosage: 50 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:651620574

Drug Label Author: Amneal Pharmaceuticals

This pill image is provided by the National Library of Medicine's PillBox.
Urecholine NDC 512850690.jpg

Drug Name: Bethanechol chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: OP;703
Dosage: 10 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:512850690

Drug Label Author: Teva Women's Health, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Urecholine NDC 512850691.jpg

Drug Name: Bethanechol chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: OP;704
Dosage: 25 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:512850691

Drug Label Author: Teva Women's Health, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Urecholine NDC 512850692.jpg

Drug Name: Bethanechol chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: OP;700
Dosage: 50 mg
Color(s): Yellow
Shape: Round
Size (mm): 11
Score: 2
NDC:512850692

Drug Label Author: Teva Women's Health, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Urecholine NDC 512850697.jpg

Drug Name: Bethanechol chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: OP;697
Dosage: 5 mg
Color(s): White
Shape: Round
Size (mm): 11
Score: 2
NDC:512850697

Drug Label Author: Teva Women's Health, Inc.

This pill image is provided by the National Library of Medicine's PillBox.
Bethanechol chloride NDC 576640104.jpg

Drug Name: Bethanechol chloride
Ingredient(s): BETHANECHOL CHLORIDE[BETHANECHOL]
Imprint: 104
Dosage: 10 mg
Color(s): White
Shape: Round
Size (mm): 12
Score: 2
NDC:576640104

Drug Label Author: Caraco Pharmaceutical Laboratories, Ltd.

This pill image is provided by the National Library of Medicine's PillBox.

Package and Label Display Panel

Bethanechol chloride 5 mg.png
This image of the FDA label is provided by the National Library of Medicine.
Bethanechol chloride 10 mg.png
This image of the FDA label is provided by the National Library of Medicine.
Bethanechol chloride 25 mg.png
This image of the FDA label is provided by the National Library of Medicine.
Bethanechol chloride 50 mg.png
This image of the FDA label is provided by the National Library of Medicine.

Patient Counseling Information

Bethanechol chloride should preferably be taken one hour before or two hours after meals to avoid nausea or vomiting. Dizziness, lightheadedness or fainting may occur, especially when getting up from a lying or sitting position.

Precautions with Alcohol

Alcohol-Bethanechol chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

There is limited information regarding Bethanechol chloride Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. "FDA LABEL: URECHOLINE- bethanechol chloride tablet".




























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