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In enzymology, a beta-ureidopropionase (EC is an enzyme that catalyzes the chemical reaction

N-carbamoyl-beta-alanine + H2O beta-alanine + CO2 + NH3

Thus, the two substrates of this enzyme are N-carbamoyl-beta-alanine and H2O, whereas its 3 products are beta-alanine, CO2, and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoyl-beta-alanine amidohydrolase. This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1R3N, 1R43, 2V8D, 2V8G, 2V8H, and 2V8V.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • CAMPBELL LL (1960). "Reductive degradation of pyrimidines. 5. Enzymatic conversion of N-carbamyl-beta-alanine to beta-alanine, carbon dioxide, and ammonia". J. Biol. Chem. 235: 2375&ndash, 8. PMID 13849303.
  • CARAVACA J, GRISOLIA S (1958). "Enzymatic decarbamylation of carbamyl beta-alanine and carbamyl beta-aminoisobutyric acid". J. Biol. Chem. 231: 357&ndash, 65. PMID 13538975.
  • Traut TW, Loechel S (1984). "Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay". Biochemistry. 23: 2533&ndash, 9. PMID 6433973.

External links

The CAS registry number for this enzyme class is 9027-27-4.

Gene Ontology (GO) codes