Difference between revisions of "Alcoholic liver disease natural history, complications and prognosis"

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==Overview==
 
==Overview==
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==Natural History==
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Alcoholic liver disease is thought to progress through four main histological stages with the continued use of alcohol.
 
==Complications==
 
==Complications==
 
====Alcoholic hepatitis====
 
====Alcoholic hepatitis====

Revision as of 13:45, 28 October 2012

Alcoholic liver disease Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Natural History

Alcoholic liver disease is thought to progress through four main histological stages with the continued use of alcohol.

Complications

Alcoholic hepatitis

  • Portal hypertension (ascites, variceal bleeding, hepatorenal syndrome)
  • Coagulopathy
  • Intractable jaundice

Cirrhosis

Prognosis

In absence of steroid therapy, 1 in every three patient dies.

Poor Prognostic Factors

Prognostic Scores

  • MELD score for cirrhosis
  • Glasgow alcoholic hepatitis score (age, white blood cell, blood urea nitrogen, prothrombin time ratio, and bilirubin level)
  • ABIC score - age, serum bilirubin, serum creatinine

2010 AASLD/ACG Alcoholic Liver Disease Guidelines : Prognostic Factors (DO NOT EDIT)[1]

Class I
1. " Patients presenting with a high clinical suspicion of alcoholic hepatitis should have their risk for poor outcome stratified using the Maddrey Discriminant Function (MDF), as well as other available clinical data. Evaluating a patient's condition over time with serial calculation of the Model for End-Stage Liver Disease (MELD) score is also justified. (Level of evidence: B) "

References

  1. "www.aasld.org" (PDF). Retrieved 2012-10-27. 

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