AP2B1

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Adaptor-related protein complex 2, beta 1 subunit
PBB Protein AP2B1 image.jpg
PDB rendering based on 1e42.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols AP2B1 ; ADTB2; AP105B; AP2-BETA; CLAPB1; DKFZp781K0743
External IDs OMIM: 601025 MGI1919020 HomoloGene68176
RNA expression pattern
PBB GE AP2B1 200615 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 163
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 71770

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000006125
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P63010
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_001030006 (mRNA)
NP_001025177 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_001035854 (mRNA)
NP_001030931 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 17: 30.94 - 31.08 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Adaptor-related protein complex 2, beta 1 subunit, also known as AP2B1, is a human gene.[1]

The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.[1]

References

  1. 1.0 1.1 "Entrez Gene: AP2B1 adaptor-related protein complex 2, beta 1 subunit".

Further reading

  • Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
  • Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741.
  • Ponnambalam S, Robinson MS, Jackson AP; et al. (1990). "Conservation and diversity in families of coated vesicle adaptins". J. Biol. Chem. 265 (9): 4814–20. PMID 1969413.
  • Gallusser A, Kirchhausen T (1994). "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". EMBO J. 12 (13): 5237–44. PMID 8262066.
  • Druck T, Gu Y, Prabhala G; et al. (1996). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.
  • Greenberg ME, Bronson S, Lock M; et al. (1998). "Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation". EMBO J. 16 (23): 6964–76. doi:10.1093/emboj/16.23.6964. PMID 9384576.
  • Lim DS, Kirsch DG, Canman CE; et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. PMID 9707615.
  • Greenberg M, DeTulleo L, Rapoport I; et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. PMID 9811611.
  • Berlioz-Torrent C, Shacklett BL, Erdtmann L; et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". J. Virol. 73 (2): 1350–61. PMID 9882340.
  • Owen DJ, Vallis Y, Pearse BM; et al. (2000). "The structure and function of the beta 2-adaptin appendage domain". EMBO J. 19 (16): 4216–27. doi:10.1093/emboj/19.16.4216. PMID 10944104.
  • Fan GH, Yang W, Wang XJ; et al. (2001). "Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization". Biochemistry. 40 (3): 791–800. PMID 11170396.
  • Swigut T, Shohdy N, Skowronski J (2001). "Mechanism for down-regulation of CD28 by Nef". EMBO J. 20 (7): 1593–604. doi:10.1093/emboj/20.7.1593. PMID 11285224.
  • Laporte SA, Miller WE, Kim KM, Caron MG (2002). "beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin". J. Biol. Chem. 277 (11): 9247–54. doi:10.1074/jbc.M108490200. PMID 11777907.
  • Collins BM, McCoy AJ, Kent HM; et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. PMID 12086608.
  • He G, Gupta S, Yi M; et al. (2003). "ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2". J. Biol. Chem. 277 (46): 44044–9. doi:10.1074/jbc.M208539200. PMID 12221107.
  • Cayrol C, Cougoule C, Wright M (2003). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun. 298 (5): 720–30. PMID 12419313.
  • Yao D, Ehrlich M, Henis YI, Leof EB (2003). "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit". Mol. Biol. Cell. 13 (11): 4001–12. doi:10.1091/mbc.02-07-0104. PMID 12429842.
  • Kalthoff C, Groos S, Kohl R; et al. (2003). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Mol. Biol. Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMID 12429846.

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