12-O-Tetradecanoylphorbol-13-acetate

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Tetradecanoylphorbol acetate
IUPAC name 12-O-tetradecanoylphorbol-13-acetate
Other names TPA, PMA, Phorbol myristate acetate,
Tetradecanoylphorbol acetate.
Identifiers
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Properties
C36H56O8
Molar mass 616.83 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as phorbol 12-myristate 13-acetate (PMA), is diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC results from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is also being studied as a drug in the treatment of hematologic cancer. TPA is not to be confused with tPA, the former is a small molecule drug, whereas the latter is an enzyme. TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It is currently undergoing phase 1 clinical trials.

References


External links

  • Tetradecanoylphorbol+Acetate at the US National Library of Medicine Medical Subject Headings (MeSH)
  • "NCI Dictionary Entry". Retrieved 2005-07-02.
  • "Phase 1 Clinical Trials". Retrieved 2005-07-02.

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