1-acylglycerol-3-phosphate O-acyltransferase

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In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References

  • IUBMB entry for 2.3.1.51
  • BRENDA references for 2.3.1.51 (Recommended.)
  • PubMed references for 2.3.1.51
  • PubMed Central references for 2.3.1.51
  • Google Scholar references for 2.3.1.51
  • Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts". Eur. J. Biochem. 129: 629&ndash, 36. PMID 6825679.
  • Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine". Biochim. Biophys. Acta. 152: 645&ndash, 8. PMID 5661029.
  • Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38: 25&ndash, 31. PMID 4774123.

External links

The CAS registry number for this enzyme class is 51901-16-7.

Gene Ontology (GO) codes


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