Jump to: navigation, search


WikiDoc Resources for Zonulin


Most recent articles on Zonulin

Most cited articles on Zonulin

Review articles on Zonulin

Articles on Zonulin in N Eng J Med, Lancet, BMJ


Powerpoint slides on Zonulin

Images of Zonulin

Photos of Zonulin

Podcasts & MP3s on Zonulin

Videos on Zonulin

Evidence Based Medicine

Cochrane Collaboration on Zonulin

Bandolier on Zonulin

TRIP on Zonulin

Clinical Trials

Ongoing Trials on Zonulin at Clinical Trials.gov

Trial results on Zonulin

Clinical Trials on Zonulin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Zonulin

NICE Guidance on Zonulin


FDA on Zonulin

CDC on Zonulin


Books on Zonulin


Zonulin in the news

Be alerted to news on Zonulin

News trends on Zonulin


Blogs on Zonulin


Definitions of Zonulin

Patient Resources / Community

Patient resources on Zonulin

Discussion groups on Zonulin

Patient Handouts on Zonulin

Directions to Hospitals Treating Zonulin

Risk calculators and risk factors for Zonulin

Healthcare Provider Resources

Symptoms of Zonulin

Causes & Risk Factors for Zonulin

Diagnostic studies for Zonulin

Treatment of Zonulin

Continuing Medical Education (CME)

CME Programs on Zonulin


Zonulin en Espanol

Zonulin en Francais


Zonulin in the Marketplace

Patents on Zonulin

Experimental / Informatics

List of terms related to Zonulin

Zonulin is a protein that participates in tight junctions between cells of the wall of the digestive tract. Initially discovered in 2000 as the target of zonula occludens toxin, secreted by cholera pathogen Vibrio cholerae,[1] it has been implicated in the pathogenesis of coeliac disease[2] and diabetes mellitus type 1.[3] It is being studied as a target for vaccine adjuvants.[4] ALBA Therapeutics is developing a zonulin receptor agonist, AT-1001, that is currently in phase 2 clinical trials.


  1. Wang W, Uzzau S, Goldblum SE, Fasano A. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci 2000;113 Pt 24:4435-40. PMID 11082037.
  2. Thomas KE, Sapone A, Fasano A, Vogel SN. Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. J Immunol 2006;176:2512-21. PMID 16456012.
  3. Sapone A, de Magistris L, Pietzak M, Clemente MG, Tripathi A, Cucca F, Lampis R, Kryszak D, Carteni M, Generoso M, Iafusco D, Prisco F, Laghi F, Riegler G, Carratu R, Counts D, Fasano A. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes 2006;55:1443-9. PMID 16644703.
  4. De Magistris MT. Zonula occludens toxin as a new promising adjuvant for mucosal vaccines. Vaccine 2006;24 Suppl 2:S2-60-1. PMID 16823929.