Von Hippel-Lindau binding protein 1
|von Hippel-Lindau binding protein 1|
|Locus||Chr. X q28|
von Hippel-Lindau–binding protein 1 (VBP1), also known as "prefoldin 3", is a chaperone protein that binds to von Hippel-Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell. It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.
VBP1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits, and is a member of the prefoldin-α subunit family. It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm. The VBP1 gene is located at Xq28. Homologues are known to exist between human VBP1 and proteins in mice, Drosophila and C. elegans.
- Tsuchiya H, Iseda T and Hino O (1996). "Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product". Cancer Research. 56: 2881–5. PMID 8674032.
- "GenAtlas report: VBP1". 2003-01-17. Retrieved 2007-07-17.
- "NiceProt report: P61758 (Prefoldin 3, human)". 2007-07-10. Retrieved 2007-07-17.
- Brinke A, Green PM and Giannelli F (1997). "Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue". Genomics. 45: 105–12. PMID 9339366.
- von+Hippel-Lindau+binding+protein+1,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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