Von Hippel-Lindau binding protein 1

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von Hippel-Lindau binding protein 1
Other data
LocusChr. X q28

von Hippel-Lindau–binding protein 1 (VBP1), also known as "prefoldin 3", is a chaperone protein that binds to von Hippel-Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell.[1] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.[2]

VBP1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,[2] and is a member of the prefoldin-α subunit family.[3] It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm.[3] The VBP1 gene is located at Xq28.[4] Homologues are known to exist between human VBP1 and proteins in mice, Drosophila and C. elegans.[2]

See also


  1. Tsuchiya H, Iseda T and Hino O (1996). "Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product". Cancer Research. 56: 2881–5. PMID 8674032.
  2. 2.0 2.1 2.2 "GenAtlas report: VBP1". 2003-01-17. Retrieved 2007-07-17.
  3. 3.0 3.1 "NiceProt report: P61758 (Prefoldin 3, human)". 2007-07-10. Retrieved 2007-07-17.
  4. Brinke A, Green PM and Giannelli F (1997). "Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue". Genomics. 45: 105–12. PMID 9339366.

External links