Vindesine

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Vindesine
Systematic (IUPAC) name
methyl (5S,7S,9S)- 9-[(2β,3β,4β,5α,12β,19α)- 3-(aminocarbonyl)- 3,4-dihydroxy- 16-methoxy- 1-methyl- 6,7-didehydroaspidospermidin- 15-yl]- 5-ethyl- 5-hydroxy- 1,4,5,6,7,8,9,10-octahydro- 2H- 3,7-methanoazacycloundecino[5,4-b]indole- 9-carboxylate
Identifiers
CAS number 59917-39-4
ATC code L01CA03
PubChem 40839
DrugBank DB00309
Chemical data
Formula C43H55N5O7 
Mol. mass 753.926 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding 65-75%
Metabolism Hepatic (CYP3A4-mediated)
Half life 24 hours
Excretion Biliary and renal
Therapeutic considerations
Pregnancy cat.

D(AU)

Legal status

Prescription only

Routes Intravenous

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.[1]

References


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