Vesicle-associated membrane protein

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Vesicle associated membrane protein (VAMP) family of proteins includes proteins with similar structure.

  • VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.
  • VAMP5 and VAMP7 (SYBL1) participate in constitutive exocytosis.
    • VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
    • VAMP7 is found both in secretory granules and endosomes.
  • VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
  • VAMP4 is involved in transport from the Golgi.[1]

References

  1. Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH (1999). "Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking". Mol. Biol. Cell. 10 (6): 1957–72. PMID 10359608.

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