Uracil mustard

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Uracil mustard
Systematic (IUPAC) name
5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Identifiers
CAS number 66-75-1
ATC code ?
PubChem 6194
DrugBank APRD00130
Chemical data
Formula C8H11Cl2N3O2 
Mol. mass 252.097 g/mol
Pharmacokinetic data
Bioavailability ?
Protein binding 5%
Metabolism ?
Half life ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

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Routes ?

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Overview

Uracil mustard or uramustine is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.



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