Ubiquitin A-52 residue ribosomal protein fusion product 1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.[1][2]

Function

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N-terminus and ribosomal protein L40 at the C-terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.[2]

Clinical significance

The cell's ribosomal protein eL40 (rpL40), a part of the large 60S subunit. rpL40 is used by certain RNA viruses to translate messenger RNAs (mRNAs) into proteins while few host mRNAs require rpL40. Hence targeting this protein may provide a means to combat viral infections with minimum side effects to the host.[3]

References

  1. Webb GC, Baker RT, Coggan M, Board PG (Jun 1994). "Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12". Genomics. 19 (3): 567–9. doi:10.1006/geno.1994.1108. PMID 8188300.
  2. 2.0 2.1 "Entrez Gene: UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1".
  3. Lee AS, Burdeinick-Kerr R, Whelan SP (November 2012). "A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs". Proc. Natl. Acad. Sci. U.S.A. 110 (1): 324–9. doi:10.1073/pnas.1216454109. PMC 3538191. PMID 23169626. Lay summaryHarvard Medical School.

Further reading



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