UDP-N-acetylglucosamine 2-epimerase

Jump to: navigation, search

In enzymology, an UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine UDP-N-acetyl-D-mannosamine

Hence, this enzyme has one substrate, UDP-N-acetyl-D-glucosamine, and one product, UDP-N-acetyl-D-mannosamine.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine 2-epimerase. Other names in common use include UDP-N-acetylglucosamine 2'-epimerase, uridine diphosphoacetylglucosamine 2'-epimerase, uridine diphospho-N-acetylglucosamine 2'-epimerase, and uridine diphosphate-N-acetylglucosamine-2'-epimerase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1F6D, 1O6C, 1V4V, and 1VGV.

References

  • IUBMB entry for 5.1.3.14
  • BRENDA references for 5.1.3.14 (Recommended.)
  • PubMed references for 5.1.3.14
  • PubMed Central references for 5.1.3.14
  • Google Scholar references for 5.1.3.14
  • Kikuchi K, Tsuiki S (1973). "Purification and properties of UDP-N-acetylglucosamine 2'-epimerase from rat liver". Biochim. Biophys. Acta. 327: 193&ndash, 206. PMID 4770741.

External links

The CAS registry number for this enzyme class is 9037-71-2.

Gene Ontology (GO) codes



Linked-in.jpg