Tyrosine-ester sulfotransferase

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In enzymology, a tyrosine-ester sulfotransferase (EC is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + L-tyrosine methyl ester adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and L-tyrosine methyl ester, whereas its two products are adenosine 3',5'-bisphosphate and L-tyrosine methyl ester 4-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase. Other names in common use include aryl sulfotransferase IV, and L-tyrosine methyl ester sulfotransferase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Duffel MW, Jakoby WB (1981). "On the mechanism of aryl sulfotransferase". J. Biol. Chem. 256: 11123&ndash, 7. PMID 6945304.
  • Mattock P, Jones JG (1970). "Partial purification and properties of an enzyme from rat liver that catalyses the sulphation of L-tyrosyl derivatives". Biochem. J. 116: 797&ndash, 803. PMID 5441369.
  • Sekura RD, Jakoby WB (1981). "Aryl sulfotransferase IV from rat liver". Arch. Biochem. Biophys. 211: 352&ndash, 9. PMID 6946725.

External links

The CAS registry number for this enzyme class is 9055-56-5.

Gene Ontology (GO) codes