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Systematic (IUPAC) name
(2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate
CAS number 299-75-2
ATC code L01AB02
PubChem 9296
Chemical data
Formula C6H14O8S2 
Mol. mass 278.30056 g·mol−1
Synonyms 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, Threitol 1,4-dimethanesulfonate, Threitol 1,4-bismethanesulfonate; L-Threitol 1,4-bis(methanesulfonate); Ovastat; Threosulphan; Treosulphan; Tresulfan
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes Oral, IV

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List of terms related to Treosulfan

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Treosulfan is a substance that is being studied in the treatment of cancer.[1] It belongs to the family of drugs called alkylating agents. It has been used mainly as a substitute of busulfan in frail patients, as the side effects and toxicity are supposedly less severe.


  1. Schmittel A, Schmidt-Hieber M, Martus P; et al. (December 2006). "A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma". Ann. Oncol. 17 (12): 1826–9. PMID 16971664. doi:10.1093/annonc/mdl309. 

External links

  • Treosulfan entry in the public domain NCI Dictionary of Cancer Terms

This article includes text from the U.S. National Cancer Institute's public domain Dictionary of Cancer Terms