Transposition of the great vessels risk factors

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Dextro-transposition of the great arteries
L-transposition of the great arteries

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Kristin Feeney, B.S. [5] Aditya Ganti M.B.B.S. [6]

Overview

TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11. Other risk factors in the mother that may increase the risk of this condition include age over 40, alcoholism, diabetes, prenatal malnutrition and rubella or other viral illness during pregnancy.

Risk factors

Generally, TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11. Other risk factors in the mother that may increase the risk of this condition include:

References

  1. Becerra JE, Khoury MJ, Cordero JF, Erickson JD (January 1990). "Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study". Pediatrics. 85 (1): 1–9. PMID 2404255.
  2. Loffredo CA, Silbergeld EK, Ferencz C, Zhang J (March 2001). "Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides". Am. J. Epidemiol. 153 (6): 529–36. doi:10.1093/aje/153.6.529. PMID 11257060.
  3. Okuda H, Nagao T (June 2006). "Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats". Congenit Anom (Kyoto). 46 (2): 97–104. doi:10.1111/j.1741-4520.2006.00109.x. PMID 16732768.



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