Toxic megacolon historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Toxic megacolon was first discovered by Marshak and Lester in 1950. Jalen criteria was developed by Jalen et al to diagnose toxic megacolon in 1969. Jalen criteria was developed by Jalen et al to diagnose toxic megacolon in 1969.

Historical Perspective

Discovery

  • Toxic megacolon was first discovered by Marshak and Lester in 1950.[1]
  • In 1950, Marshak was the first to discover the association between Clostridium difficile and the development of toxic megacolon.[2]

Landmark Events in the Development of Treatment Strategies

  • Jalen criteria was developed by Jalen et al to diagnose toxic megacolon in 1969.[3][4]

References

  1. MARSHAK RH, LESTER LJ (1950). "Megacolon a complication of ulcerative colitis". Gastroenterology. 16 (4): 768–72. PMID 14784154. 
  2. Sayedy, Leena (2010). "Toxic megacolon associatedClostridium difficilecolitis". World Journal of Gastrointestinal Endoscopy. 2 (8): 293. ISSN 1948-5190. doi:10.4253/wjge.v2.i8.293. 
  3. Longo WE, Mazuski JE, Virgo KS, Lee P, Bahadursingh AN, Johnson FE (2004). "Outcome after colectomy for Clostridium difficile colitis". Dis. Colon Rectum. 47 (10): 1620–6. PMID 15540290. 
  4. Jalan KN, Sircus W, Card WI, Falconer CW, Bruce CB, Crean GP, McManus JP, Small WP, Smith AN (1969). "An experience of ulcerative colitis. I. Toxic dilation in 55 cases". Gastroenterology. 57 (1): 68–82. PMID 5305933. 

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