Tocofersolan

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Tocofersolan
Tocophersolan.png
Names
IUPAC name
α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-poly(oxy-1,2-ethanediyl)
Other names
Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate; Liqui-E
Identifiers
3D model (JSmol)
ChemSpider
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UNII
Properties
(C2H4O)nC33H54O5
Molar mass Variable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tocofersolan (INN) or tocophersolan is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[1] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients suffering from congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[2]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[3]

References

  1. "Tocophersolan Oral". WebMD.
  2. "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
  3. Ash, Michael; Ash, Irene. Handbook of Preservatives. p. 568. ISBN 1-890595-66-7.



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