Thiamine-triphosphatase

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thiamin triphosphatase
Identifiers
EC number3.6.1.28
CAS number9068-47-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
thiamine triphosphatase
Identifiers
SymbolTHTPA
Entrez79178
HUGO18987
RefSeqNM_024328
UniProtQ9BU02
Other data
EC number3.6.1.28
LocusChr. 14 q11.2

Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction

thiamine triphosphate + H2O thiamine diphosphate + phosphate

This enzyme belongs to the family of acid anhydride hydrolases, specifically those acting on phosphorus-containing anhydrides. Its systematic name is thiamine triphosphate phosphohydrolase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.

See also

References

  • Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 (7): 2117&ndash, 9. PMID 4335862.



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