Tetrahydrofolic acid

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Tetrahydrofolic acid
Tetrahydrofolic acid.jpg
Identifiers
CAS number 29347-89-5
PubChem 1129
MeSH 5,6,7,8-tetrahydrofolic+acid
Properties
Molecular formula C19H23N7O6
Molar mass 445.43 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Tetrahydrofolic acid is a folic acid derivative.

Metabolism

Tetrahydrofolate synthesis pathway

It is produced from dihydrofolic acid by dihydrofolate reductase. This reaction is inhibited by trimethoprim.

It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase.

Functions

It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes. A shortage in THF can cause anemia.


de:Tetrahydrofolsäure




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