Terlipressin

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Terlipressin
Terlipressin.png
Clinical data
Routes of
administration
IV
ATC code
Pharmacokinetic data
Protein binding~30%
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC52H74N16O15S2
Molar mass1227.37 g/mol

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Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.

Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[2] In addition, it is used in bleeding esophageal varices.[3]
Terlipressin is marketed under the brand name Glypressin (Ferring Pharmaceuticals).

See also

References

  1. O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet. 359 (9313): 1209&ndash, 10. PMID 11955542.
  2. Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol. 33 (1): 43&ndash, 8. PMID 10905585.
  3. Ioannou G, Doust J, Rockey D. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. PMID 12535432.




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