Taxane

Jump to: navigation, search

WikiDoc Resources for Taxane

Articles

Most recent articles on Taxane

Most cited articles on Taxane

Review articles on Taxane

Articles on Taxane in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Taxane

Images of Taxane

Photos of Taxane

Podcasts & MP3s on Taxane

Videos on Taxane

Evidence Based Medicine

Cochrane Collaboration on Taxane

Bandolier on Taxane

TRIP on Taxane

Clinical Trials

Ongoing Trials on Taxane at Clinical Trials.gov

Trial results on Taxane

Clinical Trials on Taxane at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Taxane

NICE Guidance on Taxane

NHS PRODIGY Guidance

FDA on Taxane

CDC on Taxane

Books

Books on Taxane

News

Taxane in the news

Be alerted to news on Taxane

News trends on Taxane

Commentary

Blogs on Taxane

Definitions

Definitions of Taxane

Patient Resources / Community

Patient resources on Taxane

Discussion groups on Taxane

Patient Handouts on Taxane

Directions to Hospitals Treating Taxane

Risk calculators and risk factors for Taxane

Healthcare Provider Resources

Symptoms of Taxane

Causes & Risk Factors for Taxane

Diagnostic studies for Taxane

Treatment of Taxane

Continuing Medical Education (CME)

CME Programs on Taxane

International

Taxane en Espanol

Taxane en Francais

Business

Taxane in the Marketplace

Patents on Taxane

Experimental / Informatics

List of terms related to Taxane


Overview

The chemical structure of paclitaxel.

The taxanes are diterpenes produced by the plants of the genus Taxus (yews). As their name suggests, they were first derived from natural sources, but some have been synthesized artificially. Taxanes include paclitaxel and docetaxel. Paclitaxel was originally derived from the Pacific yew tree.

Taxanes have been used to produce various chemotherapy drugs. The principal mechanism of the taxane class of drugs is the disruption of microtubule function. It does this by stabilizing GDP-bound tubulin in the microtubule. Microtubules are essential to cell division, and taxanes therefore stop this - a "frozen mitosis". Thus, taxanes are essentially mitotic inhibitors. In contrast to the taxanes, the vinca alkaloids destroy mitotic spindles. Both, taxanes and vinca alkaloids are therefore named spindle poisons or mitosis poisons, but they act in different ways. Taxanes are also thought to be radiosensitizing.

External links

de:Taxane

Linked-in.jpg