Table of medication secernated in kidney

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


This is a table of medication secernated (secreted) in kidney.

Acid medication are, because of pH parturition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

Medication Location Acid or base [1] anion or cation[2] Percentage excreted[3]
para-aminohippurate proximal tubule[4] Acid anion
furosemide proximal tubule[4] Acid anion 100-75
glucuronic acid-conjugates proximal tubule[4] Acid
glycine conjugates proximal tubule[4] Acid
indometacin proximal tubule[4] Acid anion
methotrexate proximal tubule[4] Acid 100-75
penicillin proximal tubule[4] Acid anion 75-50
(benzylpenicillin)
probenecid proximal tubule[4] Acid anion
sulphate conjugates proximal tubule[4] Acid
thiazide diuretics proximal tubule[4] Acid
uric acid proximal tubule[4] Acid
amiloride proximal tubule[4] Base cation
dopamine proximal tubule[4] Base
histamine proximal tubule[4] Base
mepacrine proximal tubule[4] Base
morphine proximal tubule[4] Base cation
pethidine proximal tubule[4] Base
quaternary ammonium compounds proximal tubule[4] Base
quinine proximal tubule[4] Base cation
5 hydroxytryptamine proximal tubule[4] Base
triamterene proximal tubule[4] Base
gentamicin 100-75
atenolol 100-75
digoxin 100-75
cimetidine cation 75-50
tetracycline 75-50
(oxytetracycline)
neostigmine 75-50
propantheline ~50
tubocurarine ~50
acetazolamide proximal tubule[5] anion
chlorothiazide proximal tubule[5] anion
saccharin proximal tubule[5] anion
salicylate proximal tubule[5] anion
atropine proximal tubule[5] cation
NMN proximal tubule[5] cation
paraquat proximal tubule[5] cation
procainamide proximal tubule[5] cation
tetraethylammonium proximal tubule[5] cation
chlorpromazine proximal tubule[5] cation

References

  1. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 112
  2. Unless else specified in table boxes, then ref is Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3.  Page 802
  3. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 113
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 112
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3.  Page 802

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