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Transient receptor potential cation channel, subfamily C, member 6
Symbol(s) TRPC6; FLJ11098; FLJ14863; FSGS2; TRP6
External IDs OMIM: 603652 MGI109523 Homologene37944
Human Mouse
Entrez 7225 22068
Ensembl na ENSMUSG00000031997
Uniprot na Q61143
Refseq NM_004621 (mRNA)
NP_004612 (protein)
NM_013838 (mRNA)
NP_038866 (protein)
Location na Chr 9: 8.54 - 8.64 Mb
Pubmed search [1] [2]

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene.

TRPC6 is a transient receptor potential ion channel associated with focal segmental glomerulosclerosis.[1]


  1. Winn MP, Conlon PJ, Lynn KL; et al. (2005). "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis". Science. 308 (5729): 1801–4. PMID 15879175. doi:10.1126/science.1106215. 

Further reading

  • Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes.". Cell Calcium. 33 (5-6): 533–40. PMID 12765698. 
  • Walz G (2006). "Slit or pore? A mutation of the ion channel TRPC6 causes FSGS.". Nephrol. Dial. Transplant. 20 (9): 1777–9. PMID 15998650. doi:10.1093/ndt/gfh961. 
  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. PMID 16382100. doi:10.1124/pr.57.4.6. 
  • Schlöndorff JS, Pollak MR (2007). "TRPC6 in glomerular health and disease: what we know and what we believe.". Semin. Cell Dev. Biol. 17 (6): 667–74. PMID 17116414. doi:10.1016/j.semcdb.2006.11.003. 
  • Dietrich A, Gudermann T (2007). "TRPC6.". Handb Exp Pharmacol (179): 125–41. PMID 17217054. doi:10.1007/978-3-540-34891-7_7. 

External links