TRPA (channel)

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transient receptor potential cation channel, subfamily A, member 1
Identifiers
Symbol TRPA1
Alt. Symbols ANKTM1
Entrez 8989
HUGO 497
OMIM 604775
RefSeq NM_007332
UniProt O75762
Other data
Locus Chr. 8 q13


Overview

TRPA is a family of transient receptor potential ion channels.

The sole member of the TRPA sub-family, TRPA1, contains 14 N-terminal ankyrin repeats and is believed to function as a mechanical stress sensor. It is expressed in the dorsal root ganglion, trigeminal ganglion, and hair cells. The temperature sensitivity of TRPA1 is highly disputed, with some reports claiming that it is activated by noxiously cold stimuli and others disputing such a claim. TRPA1 is known to be activated by isothiocyanates, which are the pungent chemicals in substances such as mustard oil and wasabi, methyl salicylate in winter green oil, and cinnamaldehyde in cinnamon, amongst numerous other substances.[1]

References

  1. Nilius B, Owsianik G, Voets T, Peters JA (2007). "Transient receptor potential cation channels in disease". Physiol. Rev. 87 (1): 165–217. PMID 17237345. 

External links


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