tRNA sulfurtransferase

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In enzymology, a tRNA sulfurtransferase (EC is an enzyme that catalyzes the chemical reaction

L-cysteine + 'activated' tRNA L-serine + tRNA containing a thionucleotide

Thus, the two substrates of this enzyme are L-cysteine and 'activated' tRNA, whereas its two products are L-serine and tRNA containing a thionucleotide.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is L-cysteine:tRNA sulfurtransferase. Other names in common use include transfer ribonucleate sulfurtransferase, RNA sulfurtransferase, ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, and transfer RNA thiolase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Abrell JW, Kaufman EE, Lipsett MN (1971). "The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system". J. Biol. Chem. 246: 294&ndash, 301. PMID 5541999.
  • Hayward RS, Weiss SB (1966). "RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts". Proc. Natl. Acad. Sci. U. S. A. 55: 1161&ndash, 8. PMID 5334200.
  • Lipsett MN, Peterkofsky A (1966). "Enzymatic thiolation of E. coli sRNA". Proc. Natl. Acad. Sci. U. S. A. 55: 1169&ndash, 74. PMID 5334201.
  • Wong TW, Weiss SB, Eliceiri GL, Bryant J (1970). "Ribonucleic acid sulfurtransferase from Bacillus subtilis W168 Sulfuration with beta-mercaptopyruvate and properties of the enzyme system". Biochemistry. 9: 2376&ndash, 86. PMID 4987417.

External links

The CAS registry number for this enzyme class is 9055-57-6.

Gene Ontology (GO) codes