TNFRSF12A

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.[1][2][3]

Clinical significance

NFAT1 regulates the expression of TWEAKR (this protein) and its ligand TWEAK with lipocalin 2 to increase breast cancer cell invasion.[4]

References

  1. Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA (Jun 2000). "The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas". Am J Pathol. 156 (4): 1253–61. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.
  2. Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA (Jan 2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J Biol Chem. 274 (46): 33166–76. doi:10.1074/jbc.274.46.33166. PMID 10551889.
  3. "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".
  4. Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S (October 2012). "Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion" (PDF). J. Cell Sci. 125 (Pt 19): 4475–86. doi:10.1242/jcs.099879. PMID 22767506.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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