TGF beta receptors

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transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa)
Identifiers
SymbolTGFBR1
Entrez7046
HUGO11772
OMIM190181
RefSeqNM_004612
UniProtP36897
Other data
LocusChr. 9 q22
transforming growth factor beta, receptor type II (70/80kDa)
Identifiers
SymbolTGFBR2
Alt. symbolsMFS2
Entrez7048
HUGO11773
OMIM190182
RefSeqNM_001024847
UniProtP37173
Other data
LocusChr. 3 p22
transforming growth factor beta, receptor type III
Identifiers
SymbolTGFBR3
Entrez7049
HUGO11774
OMIM600742
RefSeqNM_003243
UniProtQ03167
Other data
LocusChr. 1 p33-p32

TGFβ receptors are single pass serine/threonine kinase receptors. They exist in several different isoforms that can be homo- or heterodimeric.[1] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.

TGF can be found in many different tissue types, including brain, heart, kidney, liver and testes. Over-expression of TGF can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease (ESRD). Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.

Classification

Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand binding affinities and can only be distinguished from each other by peptide mapping, both receptor types I and II have a high affinity for TGF-β1 and low affinity for TGF-β2. TGF-β receptor type III has a high affinity for both TGF-β1 and -β2 and in addition TGF-β1.2.[2]

Genes

References

  1. Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells. J Biol Chem. 1998 Nov 27; 273(48): 31770-7; PMID 9822641 Free text
  2. Cheifetz S, Andres JL and Massague J. (1988). "The transforming growth factor-beta receptor type III is a membrane proteoglycan". J. Biol. Chem. 263 (32): 16984–16991. PMID 2903157.

External links


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