TBL1XR1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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F-box-like/WD repeat-containing protein TBL1XR1 is a protein that in humans is encoded by the TBL1XR1 gene.[1][2][3]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.[3] Mutations in TBL1XR1 have been identified in lymphomas, including MYD88 wild-type Waldenstrom's Macroglobulinemia[4]

Interactions

TBL1XR1 has been shown to interact with Nuclear receptor co-repressor 1.[2][5][6]

References

  1. Zhang X, Dormady SP, Basch RS (Jan 2001). "Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors". Exp Hematol. 28 (11): 1286–96. doi:10.1016/S0301-472X(00)00539-7. PMID 11063877.
  2. 2.0 2.1 Zhang J, Kalkum M, Chait BT, Roeder RG (Apr 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol Cell. 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.
  3. 3.0 3.1 "Entrez Gene: TBL1XR1 transducin (beta)-like 1X-linked receptor 1".
  4. Hunter et al, Proc. American Society for Hematology 2017; Abstract 4011
  5. Yoon, Ho-Geun; Chan Doug W; Reynolds Albert B; Qin Jun; Wong Jiemin (Sep 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell. United States. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. ISSN 1097-2765. PMID 14527417.
  6. Yoon, Ho-Geun; Chan Doug W; Huang Zhi-Qing; Li Jiwen; Fondell Joseph D; Qin Jun; Wong Jiemin (Mar 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. England. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMC 151047. PMID 12628926.

Further reading




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