TASP1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Threonine aspartase 1 is an enzyme that in humans is encoded by the TASP1 gene.[1][2]

Function

This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Cleavage of TFIIA has been found to drive spermatogenesis.[3]

Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]

Clinical significance

Taspase1 is overexpressed in primary human cancers and functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Therefore, Taspase1 may serve as a novel anti-cancer therapeutic target.[4]

References

  1. Hsieh JJ, Cheng EH, Korsmeyer SJ (Nov 2003). "Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression". Cell. 115 (3): 293–303. doi:10.1016/S0092-8674(03)00816-X. PMID 14636557.
  2. 2.0 2.1 "Entrez Gene: TASP1 taspase, threonine aspartase, 1".
  3. Oyama, T; Sasagawa, S; Takeda, S; Hess, R. A.; Lieberman, P. M.; Cheng, E. H.; Hsieh, J. J. (2013). "Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs". Developmental Cell. 27 (2): 188–200. doi:10.1016/j.devcel.2013.09.025. PMC 3947863. PMID 24176642.
  4. Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ (July 2010). "Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis". Cancer Res. 70 (13): 5358–67. doi:10.1158/0008-5472.CAN-10-0027. PMC 2909739. PMID 20516119.

Further reading




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