TAS2R9

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
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RefSeq (mRNA)

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RefSeq (protein)

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Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.[1][2][3]

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium.[4]

See also

References

  1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
  2. Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
  3. 3.0 3.1 "Entrez Gene: TAS2R9 taste receptor, type 2, member 9".
  4. Allen AL, McGeary JE, Knopik VS, Hayes JE (2013). "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31". Chem. Senses. 38 (5): 379–89. doi:10.1093/chemse/bjt017. PMC 3657735. PMID 23599216.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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