Syphilis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Aslam, M.B.B.S[2]

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Overview

Other diagnostic studies which may help diagnose complications of syphilis are CSF examination, screening tests for other STIs such as HIV, chlamydia, gonorrhea, and biopsy.[1][2]

Other Diagnostic Studies

Other diagnostic studies which may help diagnose complications of syphilis are:[1][2]

CSF examination

  • May help to diagnose neurosyphilis
  • Includes CSF cell count or protein and a reactive CSF-VDRL or CSF FTA-ABS test
  • CSF-VDRL is highly specific but insensitive
  • CSF FTA-ABS test is less specific for neurosyphilis than the CSF-VDRL but is highly sensitive

Screening tests for other STIs

Biopsy

  • Biopsy may be considered if clinical findings do not correlate with negative serological tests and there is a strong index of suspicion for syphilis.

References

  1. 1.0 1.1 http://www.cdc.gov/std/tg2015/syphilis.htm accessed on September 28, 2016
  2. 2.0 2.1 Luger AF, Schmidt BL, Kaulich M (2000). "Significance of laboratory findings for the diagnosis of neurosyphilis". Int J STD AIDS. 11 (4): 224–34. PMID 10772085.

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