Sodium picosulfate

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Sodium picosulfate
Systematic (IUPAC) name
disodium 2-[bis(4-sulfonatooxyphenyl)methyl]pyridine
CAS number 10040-45-6
ATC code A06AB08 A06AB58
PubChem 68654
Chemical data
Formula C18H13NNa2O8S2 
Mol. mass 481.409 g/mol
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes Oral

Sodium picosulfate (INN, also known as sodium picosulphate) is a contact laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. It is sold under the trade names Dulcolax, Laxoberal, Picolax, Guttalax and several others.

Side effects

The most common side effects of picosulfate are abdominal cramps and diarrhea.

The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.[1]


  1. ADRAC (2002). "Electrolyte disturbances with sodium picosulfate bowel cleansing products". Aust Adv Drug React Bull. 21 (1).  Free full text from the Australian Therapeutic Goods Administration