Slipped strand mispairing

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Mutation process which occurs during DNA replication. It involves denaturation and displacement of the DNA strands, resulting in mispairing of the complementary bases. Slipped strand mispairing is one explanation for the origin and evolution of Satellite DNA. [1] Slipped Strand Mispairing has also been shown to function as a phase variation mechanism in certain bacteria. [2]


  1. Levinson, G. & Gutman, G. A. (1987). "Slipped-Strand Mispairing: A Major Mechanism for DNA Sequence Evolution". Mol. Biol. Evol. 4 (3): 203–221.
  2. Torres-Cruz, Joshua and van der Woude, Marjan W. (2003). "Slipped-Strand Mispairing Can Function as a Phase Variation Mechanism in Escherichia coli". Journal of Bacteriology: 6990–6994.