Seizure threshold 2 homolog is a protein that in humans is encoded by the SZT2 gene.
The protein encoded by this gene is expressed in the brain, predominantly in the parietal and
frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis.
Mutations in this gene have been shown to cause infantile
encephalopathy with epilepsy and dysmorphic corpus callosum.
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"Entrez Gene: Seizure threshold 2 homolog (mouse)".
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