STK3

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External IDsGeneCards: [1]
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Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.[1][2]

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).[supplied by OMIM][2]

References

  1. Taylor LK, Wang HC, Erikson RL (Nov 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc Natl Acad Sci U S A. 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
  2. 2.0 2.1 "Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)".

Further reading




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