SLCO1B3

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[1]

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[2] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[3]

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[3]

Substrates

Small molecules that are transported by SLCO1B3 include:[4]

See also

References

  1. "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
  2. Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD (June 2008). "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer". Clin. Cancer Res. 14 (11): 3312–8. doi:10.1158/1078-0432.CCR-07-4118. PMC 2701141. PMID 18519758.
  3. 3.0 3.1 Heather Pressler; Tristan M. Sissung; David Venzon; Douglas K. Price; William D. Figg (May 2011). "Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression". Clin. Cancer Res. 6 (5): e20372. Bibcode:2011PLoSO...620372P. doi:10.1371/journal.pone.0020372. PMC 3098289. PMID 21625523.
  4. Hagenbuch B, Gui C (July 2008). "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family". Xenobiotica. 38 (7–8): 778–801. doi:10.1080/00498250801986951. PMID 18668430.

Further reading



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