SLC6A5

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Solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Identifiers
Symbols SLC6A5 ; GLYT2; NET1
External IDs OMIM: 604159 MGI105090 HomoloGene37901
RNA expression pattern
File:PBB GE SLC6A5 210810 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 9152
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 104245

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000165970
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q9Y345
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_004211 (mRNA)
NP_004202 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_148931 (mRNA)
NP_683733 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 11: 20.58 - 20.63 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Solute carrier family 6 (neurotransmitter transporter, glycine), member 5, also known as SLC6A5, is a human gene.[1]


See also

References

  1. "Entrez Gene: SLC6A5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5".

Further reading

  • López-Corcuera B, Aragón C, Geerlings A (2002). "Regulation of glycine transporters". Biochem. Soc. Trans. 29 (Pt 6): 742–5. PMID 11709067.
  • Morrow JA, Collie IT, Dunbar DR; et al. (1998). "Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome". FEBS Lett. 439 (3): 334–40. PMID 9845349.
  • Gallagher MJ, Burgess LH, Brunden KR (1999). "Characterization of multiple forms of the human glycine transporter type-2". Brain Res. Mol. Brain Res. 70 (1): 101–15. PMID 10381548.
  • Evans J, Herdon H, Cairns W; et al. (2000). "Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter". FEBS Lett. 463 (3): 301–6. PMID 10606742.
  • Martínez-Maza R, Poyatos I, López-Corcuera B; et al. (2001). "The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2". J. Biol. Chem. 276 (3): 2168–73. doi:10.1074/jbc.M006774200. PMID 11036075.
  • Geerlings A, Núñez E, Rodenstein L; et al. (2002). "Glycine transporter isoforms show differential subcellular localization in PC12 cells". J. Neurochem. 82 (1): 58–65. PMID 12091465.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Mahendrasingam S, Wallam CA, Hackney CM (2003). "Two approaches to double post-embedding immunogold labeling of freeze-substituted tissue embedded in low temperature Lowicryl HM20 resin". Brain Res. Brain Res. Protoc. 11 (2): 134–41. PMID 12738009.
  • Baliova M, Betz H, Jursky F (2004). "Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2". J. Neurochem. 88 (1): 227–32. PMID 14675166.
  • Tsutsumi S, Kamata N, Vokes TJ; et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMID 15124103.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Jamra RA, Villela AW, Klein K; et al. (2006). "No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia". Psychiatr. Genet. 16 (3): 91. doi:10.1097/01.ypg.0000199450.07786.ab. PMID 16691125.
  • Rees MI, Harvey K, Pearce BR; et al. (2006). "Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease". Nat. Genet. 38 (7): 801–6. doi:10.1038/ng1814. PMID 16751771.
  • Eulenburg V, Becker K, Gomeza J; et al. (2006). "Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia". Biochem. Biophys. Res. Commun. 348 (2): 400–5. doi:10.1016/j.bbrc.2006.07.080. PMID 16884688.

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