SLC39A1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[1] [2][3]

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[4]


See also

References

  1. Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
  2. Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
  3. "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
  4. Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Further reading



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