SLC37A1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 37 (glucose-6-phosphate transporter), member 1 is a protein that in humans is encoded by the SLC37A1 gene.[1] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.[2]

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis[3], but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.[4]

References

  1. "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
  2. "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
  3. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLoS One. 6 (9): e23157. doi:10.1371/journal.pone.0023157. PMC 3176764. PMID 21949678.
  4. Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17: 858. doi:10.1186/s12864-016-3175-3. PMC 5094043. PMID 27809761.

Further reading


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