Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14gene.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene.
↑Sanchis D, Fleury C, Chomiki N, Goubern M, Huang Q, Neverova M, Gregoire F, Easlick J, Raimbault S, Levi-Meyrueis C, Miroux B, Collins S, Seldin M, Richard D, Warden C, Bouillaud F, Ricquier D (Jan 1999). "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast". J Biol Chem. 273 (51): 34611–5. doi:10.1074/jbc.273.51.34611. PMID9852133.
Jezek P, Urbánková E (2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life. 49 (1): 63–70. doi:10.1080/713803586. PMID10772343.
Yu XX, Mao W, Zhong A, et al. (2000). "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation". FASEB J. 14 (11): 1611–8. doi:10.1096/fj.14.11.1611. PMID10928996.
Kim-Han JS, Reichert SA, Quick KL, Dugan LL (2001). "BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production". J. Neurochem. 79 (3): 658–68. doi:10.1046/j.1471-4159.2001.00604.x. PMID11701769.
Yang X, Pratley RE, Tokraks S, et al. (2002). "UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates". Mol. Genet. Metab. 75 (4): 369–73. doi:10.1016/S1096-7192(02)00008-2. PMID12051969.
Ho PW, Chu AC, Kwok KH, et al. (2007). "Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity". J. Neurosci. Res. 84 (6): 1358–66. doi:10.1002/jnr.21034. PMID16941493.
Yasuno K, Ando S, Misumi S, et al. (2007). "Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2): 250–3. doi:10.1002/ajmg.b.30443. PMID17066476.