SLC22A1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.[1][2]

Function

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[2]

It is also required for the uptake of metformin by cells.[3][4]

See also

References

  1. Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenetics and Cell Genetics. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
  2. 2.0 2.1 "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1".
  3. Pryor, R; Cabreiro, F; Haberland, G (16 October 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". Biochemical Journal. 471 (3): 307–322. doi:10.1042/BJ20150497. PMC 4613459. PMID 26475449.
  4. Rosilio, C; Ben-Sahra, I; Bost, F; Peyron, JF (1 May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia". Cancer Letters. 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID 24462823.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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