SLC16A1

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Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Identifiers
Symbols SLC16A1 ; MCT1; FLJ36745; MCT; MGC44475
External IDs OMIM: 600682 MGI106013 HomoloGene20662
RNA expression pattern
File:PBB GE SLC16A1 202236 s at tn.png
File:PBB GE SLC16A1 202234 s at tn.png
File:PBB GE SLC16A1 202235 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 6566
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 20501

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000155380
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000032902

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P53985
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3TIU1

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_003051 (mRNA)
NP_003042 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_009196 (mRNA)
NP_033222 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 1: 113.26 - 113.3 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 3: 104.77 -  104.79 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Solute carrier family 16, member 1 (monocarboxylic acid transporter 1), also known as SLC16A1, is a human gene.[1]


References

  1. "Entrez Gene: SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)".

Further reading

  • Bonen A (2002). "The expression of lactate transporters (MCT1 and MCT4) in heart and muscle". Eur. J. Appl. Physiol. 86 (1): 6–11. PMID 11820324.
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.
  • Kim CM, Goldstein JL, Brown MS (1992). "cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function". J. Biol. Chem. 267 (32): 23113–21. PMID 1429658.
  • Garcia CK, Li X, Luna J, Francke U (1995). "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12". Genomics. 23 (2): 500–3. doi:10.1006/geno.1994.1532. PMID 7835905.
  • Garcia CK, Goldstein JL, Pathak RK; et al. (1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. PMID 8124722.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
  • Ritzhaupt A, Wood IS, Ellis A; et al. (1999). "Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate". J. Physiol. (Lond.). 513 ( Pt 3): 719–32. PMID 9824713.
  • Rahman B, Schneider HP, Bröer A; et al. (1999). "Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1". Biochemistry. 38 (35): 11577–84. doi:10.1021/bi990973f. PMID 10471310.
  • Brooks GA, Brown MA, Butz CE; et al. (1999). "Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1". J. Appl. Physiol. 87 (5): 1713–8. PMID 10562613.
  • Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW (2000). "Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport". Muscle Nerve. 23 (1): 90–7. PMID 10590411.
  • Kirk P, Wilson MC, Heddle C; et al. (2000). "CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression". EMBO J. 19 (15): 3896–904. doi:10.1093/emboj/19.15.3896. PMID 10921872.
  • Cuff MA, Lambert DW, Shirazi-Beechey SP (2002). "Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1". J. Physiol. (Lond.). 539 (Pt 2): 361–71. PMID 11882670.
  • Cuff MA, Shirazi-Beechey SP (2002). "The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis". Biochem. Biophys. Res. Commun. 292 (4): 1048–56. doi:10.1006/bbrc.2002.6763. PMID 11944921.
  • Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP (2002). "Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy". Br. J. Cancer. 86 (8): 1262–9. doi:10.1038/sj.bjc.6600264. PMID 11953883.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Zhang GZ, Huang GJ, Li WL; et al. (2002). "[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells]". Ai Zheng. 21 (7): 719–23. PMID 12479094.
  • Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. PMID 12657613.
  • Asada K, Miyamoto K, Fukutomi T; et al. (2003). "Reduced expression of GNA11 and silencing of MCT1 in human breast cancers". Oncology. 64 (4): 380–8. doi:10.1159/000070297. PMID 12759536.

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