SENP8

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.[1][2][3]

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003).[supplied by OMIM][3]

References

  1. Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT (Jul 2003). "NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins". J Biol Chem. 278 (28): 25637–43. doi:10.1074/jbc.M212948200. PMID 12730221.
  2. Gan-Erdene T, Nagamalleswari K, Yin L, Wu K, Pan ZQ, Wilkinson KD (Jul 2003). "Identification and characterization of DEN1, a deneddylase of the ULP family". J Biol Chem. 278 (31): 28892–900. doi:10.1074/jbc.M302890200. PMID 12759362.
  3. 3.0 3.1 "Entrez Gene: SENP8 SUMO/sentrin specific peptidase family member 8".

Further reading




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